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Effect on Lymphocyte Class, Subset, and Response to Early Antigen

Alice Brandfonbrener, MD; Alan Epstein, MD, PhD; Samuel Wu, MS; John Phair, MD

Arch Intern Med. 1986;146(2):337-339.

Abstract
• Corticosteroid treatment of impending upper airway obstruction due to Epstein-Barr virus (EBV) infectious mononucleosis did not alter the pattern of lymphocyte changes induced by this viral infection during the first two weeks following administration of prednisone. By 12 weeks, 11 treated students had significantly fewer lymphocytes, including B, total T, helper, and T-suppressor cell numbers, than 11 untreated EBV-infected students, and values were closer to those noted in uninfected controls. Corticosteroid therapy did not alter the serologic response to early antigens of EBV. Fever and lymphadenopathy resolved somewhat more quickly in treated students.

(Arch Intern Med 1986;146:337-339)

Author Affiliations
From the Student Health Service, Northwestern University (Dr Brandfonbrener), and the Sections of Oncology (Dr Epstein) and Infectious Disease (Dr Phair and Mr Wu), Department of Medicine, Northwestern University Medical School, Chicago. Dr Epstein is now with the Department of Pathology, University of Southern California Medical Center, Los Angeles.

Footnotes
Accepted for publication May 15, 1985.

Reprint requests to Department of Medicine, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611 (Dr Phair).

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