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Development in Two Patients Receiving a Potassium-Sparing Diuretic and Total Parenteral Nutrition

Robert F. Kushner, MD; Michael D. Sitrin, MD

Arch Intern Med. 1986;146(2):343-345.

Abstract
• Two patients developed a metabolic acidosis associated with a normal undetermined anion concentration while receiving a potassium-sparing diuretic and total parenteral nutrition. In both cases the metabolic acidosis resolved within one week after discontinuing administration of the diuretic. The use of potassium-sparing diuretics in a patient receiving total parenteral nutrition requires caution and continued monitoring for this potential drug-nutrient interaction.

(Arch Intern Med 1986;146:343-345)

Author Affiliations
From the Section of Gastroenterology, Department of Medicine and the Nutrition Support Service, University of Chicago.

Footnotes
Accepted for publication May 28, 1985.

Reprint requests to Box 223, University of Chicago, 5841S Maryland Ave, Chicago, IL 60637 (Dr Kushner).

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ABSTRACT