 |
|
Immune Thrombocytopenia and Response to Splenectomy in Chronic Liver Disease
Samuel A. Skootsky, MD;
Michael H. Rosove, MD;
Mary B. Langley, MS
Arch Intern Med. 1986;146(3):555-557.
Abstract
• Six patients had chronic liver diseases of diverse origin, persistent unexplained thrombocytopenia, and no palpable splenic enlargement. Platelet-associated IgG levels were increased in all cases. Two patients underwent splenectomy; the spleens weighed 375 and 230 g. Each patient had prompt, complete, and sustained platelet count normalization. Two other patients treated briefly with prednisone had no response. These observations indicate that a minimally enlarged spleen may be responsible for thrombocytopenia in chronic liver disease and suggest that immune mechanisms may contribute to thrombocytopenia in this setting.
(Arch Intern Med 1986;146:555-557)
Author Affiliations
From the Divisions of General Internal Medicine and Health Services Research (Dr Skootsky) and Hematology/Oncology (Dr Rosove), Department of Medicine, and the Clinical Laboratories (Ms Langley), School of Medicine, UCLA School for the Health Sciences.
Footnotes
Accepted for publication June 24, 1985.
Reprint requests to Department of Medicine, UCLA School of Medicine, Division of General Internal Medicine and Health Services Research, B-551 Louis Factor Bldg, UCLA Center for the Health Sciences, Los Angeles, CA 90024 (Dr Skootsky).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Splenectomy for Thrombocytopenia in Chronic Liver Disease
Crosby
Arch Intern Med 1987;147:195-195.
ABSTRACT
|
