This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Carol E. Peterson, MD; Hau C. Kwaan, MD

Arch Intern Med. 1986;146(3):581-584.

Abstract
• Oral anticoagulants are used extensively, although their risks are not always fully recognized. The prophylaxis of venous thrombosis after hip surgery, the prevention of deep venous thrombosis and pulmonary emboli after an acute episode of these, the prevention of arterial emboli from the heart in patients at risk, and the prophylaxis of thrombosis in patients with congenital deficiency of antithrombin III, protein C, or protein S are some of the indications for oral anticoagulant use. Warfarin sodium is contraindicated in pregnancy, however. The recommended prothrombin time is 1 to two times control, lower than previously. The major risk of oral anticoagulant therapy, bleeding, is treated with vitamin K or plasma, depending on its severity. Warfarin necrosis and the "purple-toe" syndrome are seen more frequently than realized.

(Arch Intern Med 1986;146:581-584)

Author Affiliations
From the Section of Hematology/Oncology, Department of Medicine, Northwestern University, and the Department of Hematology/Oncology, Veterans Administration Lakeside Medical Center, Chicago.

Footnotes
Accepted for publication May 28, 1985.

Reprint requests to Department of Hematology/Oncology, Veterans Administration Lakeside Medical Center, 333 E Huron St, Chicago, IL 60611 (Dr Kwaan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Postanalytical External Quality Assessment of Warfarin Monitoring in Primary Healthcare
Kristoffersen et al.
Clin. Chem. 2006;52:1871-1878.
ABSTRACT | FULL TEXT  

Warfarin-Induced Skin Necrosis: A Case Report
Abdul-Jabar et al.
CLIN APPL THROMB HEMOST 2006;12:101-104.
ABSTRACT  

A Structured Teaching and Self-management Program for Patients Receiving Oral Anticoagulation: A Randomized Controlled Trial
Sawicki and for the Working Group for the Study of Patient Sel
JAMA 1999;281:145-150.
ABSTRACT | FULL TEXT  

Warfarin Necrosis
McKnight et al.
Arch Fam Med 1992;1:105-108.
ABSTRACT  

Anticoagulant-Induced Shoulder Hematoma Producing Brachial Plexus Neuropathy Case Reports
Frangides and Kounis
ANGIOLOGY 1992;43:701-705.
ABSTRACT  

Protein C Deficiency: A Cause of Unusual or Unexplained Thrombosis
Tollefson et al.
Arch Surg 1988;123:881-884.
ABSTRACT  

The Medical Review Article: State of the Science
MULROW
ANN INTERN MED 1987;106:485-488.
ABSTRACT