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Safety and Feasibility in Stable Angina Pectoris

Michael D. Winniford, MD; Kay L. Fulton, RN; L. David Hillis, MD

Arch Intern Med. 1986;146(4):795.

Abstract
• To study the safety and feasibility of abruptly changing antianginal therapy from propranolol hydrochloride to verapamil, we gave propranolol to ten patients with stable angina and coronary artery disease for 14 days, then, on day 15, we began verapamil therapy, which continued for 14 more days. Anginal frequency and nitroglycerin use were similar throughout the study. No patient had symptomatic bradycardia or atrioventricular block. Such crossover therapy is effective when propranolol is replaced by verapamil abruptly.

(Arch Intern Med 1986;146:795)

Author Affiliations
From the Department of Internal Medicine, Cardiovascular Division, University of Texas Health Science Center, Dallas. Dr Hillis is an established investigator of the American Heart Association, Dallas.

Footnotes
Accepted for publication Oct 7, 1985.

Reprint requests to Room L5.134, University of Texas Health Science Center, 5323 Harry Hines Blvd, Dallas, TX 75235 (Dr Hillis).

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