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Low- vs High-Dose AspirinEffects on Platelet Function in Hyperlipoproteinemic and Normal Subjects
Marjorie L. Zucker, MD;
Cynthia Trowbridge, MT(ASCP);
Janet Woodroof, MT(ASCP);
Steven B. Chernoff, PhD;
Lance Reynoso;
Carlos A. Dujovne, MD
Arch Intern Med. 1986;146(5):921-925.
Abstract
• Low-dose aspirin may be inadequate for inhibition of platelet function in hyperlipoproteinemics due to increased platelet reactivity. Platelet function was studied in 18 type II hyperlipoproteinemic and 12 normal subjects after at least ten days of treatment with placebo and with low-dose (0.45 mg/kg/day) and high-dose (900 mg/day) aspirin. In the normal and hyperlipoproteinemic subjects, low-dose aspirin produced near maximal (90%) inhibition of platelet thromboxane generation, significant prolongation of the bleeding time, and significant inhibition of platelet aggregation, similar in degree to the inhibition produced by high-dose aspirin. There was no significant difference between hyperlipoproteinemic and normal subjects in any of the platelet function measures before and after aspirin treatment. Thus, a daily 0.45-mg/kg aspirin dose (20 to 45 mg) effectively inhibited platelet function in type II hyperlipoproteinemics, who do not appear to have an increased dose requirement for aspirin.
(Arch Intern Med 1986;146:921-925)
Author Affiliations
From the Department of Pathology (Dr Zucker and Mss Trowbridge and Woodroof) and the Lipid and Arteriosclerosis Prevention Clinic, Division of Clinical Pharmacology, Department of Medicine (Drs Chernoff and Dujovne and Mr Reynoso), University of Kansas School of Medicine, Kansas City.
Footnotes
Accepted for publication Sept 3, 1985.
Read in part before the International Union of Pharmacology Ninth International Congress on Pharmacology, London, Aug 3, 1984.
Reprint requests to Department of Pathology, University of Kansas School of Medicine, Rainbow Boulevard at 39th Street, Kansas City, KS 66103 (Dr Zucker).
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ABSTRACT
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