Occult Ectopic Secretion of Corticotropin

doi:10.1001/archinte.1986.00360170151022

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 146 No. 5, May 1986

Online Only
	•	Online First Table of Contents

ORIGINAL INVESTIGATIONS

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (117)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Occult Ectopic Secretion of Corticotropin

James W. Findling, MD; J. Blake Tyrrell, MD

Arch Intern Med. 1986;146(5):929-933.

Abstract

• The clinical, biochemical, radiographic, and morphologicfeatures of ectopic corticotropin (ACTH)-dependent Cushing'ssyndrome are often indistinguishable from those of Cushing'sdisease (pituitary-dependent Cushing's syndrome). We encounteredten patients whose ectopic ACTH-secreting neoplasms were notclinically apparent for two months to 12 years after the diagnosisof hypercortisolism or in whom the site remains unknown. Fiveof these patients underwent unnecessary pituitary microsurgery,and a sixth was referred for surgery. The occult ectopic ACTHsyndrome occurs with equal frequency in men and women and hypokalemiais present in 60%, in contrast to the female predominance andrarity of hypokalemia in Cushing's disease. We emphasize theimportance of selective venous sampling for ACTH to establishthe correct diagnosis. Thirty-nine similar cases from the literaturehelp characterize this syndrome further.

(Arch Intern Med 1986;146:929-933)

Author Affiliations

From the Department of Medicine, St Luke's Hospital, Medical College of Wisconsin, Milwaukee (Dr Findling), and the Metabolic Research Unit and Department of Medicine, University of California, San Francisco (Dr Tyrrell).

Footnotes

Accepted for publication Aug 6, 1985.

Reprint requests to Department of Medicine, St Luke's Hospital,2900 W Oklahoma Ave, Milwaukee, WI 53215 (Dr Findling).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Utility of Various Functional and Anatomic Imaging Modalities for Detection of Ectopic Adrenocorticotropin-Secreting Tumors
Zemskova et al.
J. Clin. Endocrinol. Metab. 2010;95:1207-1219.
ABSTRACT | FULL TEXT

Management of Cushing's Syndrome due to Ectopic Adrenocorticotropin Secretion with 1,Ortho-1, Para'-Dichloro-Diphenyl-Dichloro-Ethane: Findings in 23 Patients from a Single Center
Donadille et al.
J. Clin. Endocrinol. Metab. 2010;95:537-544.
ABSTRACT | FULL TEXT

The Ectopic Adrenocorticotropin Syndrome: Clinical Features, Diagnosis, Management, and Long-Term Follow-Up
Isidori et al.
J. Clin. Endocrinol. Metab. 2006;91:371-377.
ABSTRACT | FULL TEXT

Cushing's Syndrome Due to Ectopic Corticotropin Secretion: Twenty Years' Experience at the National Institutes of Health
Ilias et al.
J. Clin. Endocrinol. Metab. 2005;90:4955-4962.
ABSTRACT | FULL TEXT

Diagnostic Errors after Inferior Petrosal Sinus Sampling
Swearingen et al.
J. Clin. Endocrinol. Metab. 2004;89:3752-3763.
ABSTRACT | FULL TEXT

Bilateral Inferior Petrosal Sinus Sampling in the Differential Diagnosis of Adrenocorticotropin-Dependent Cushing's Syndrome: A Comparison with Other Diagnostic Tests
Wiggam et al.
J. Clin. Endocrinol. Metab. 2000;85:1525-1532.
ABSTRACT | FULL TEXT

Is whole-lung CT scanning still necessary in all cases of ACTH-dependent Cushing's syndrome in the era of petrosal sinus sampling?
Heaney et al.
QJM 1999;92:335-340.
ABSTRACT | FULL TEXT

The Diagnosis and Differential Diagnosis of Cushing's Syndrome and Pseudo-Cushing's States
Newell-Price et al.
Endocr Rev 1998;19:647-672.
ABSTRACT | FULL TEXT

The Cushing Syndrome Induced by Bronchial Carcinoid Tumors
Limper et al.
ANN INTERN MED 1992;117:209-214.
ABSTRACT

Management of the ectopic ACTH syndrome due to thoracic carcinoids
Pass et al.
Ann. Thorac. Surg. 1990;50:52-57.
ABSTRACT

The Cushing Syndrome: An Update on Diagnostic Tests
Kaye and Crapo
ANN INTERN MED 1990;112:434-444.
ABSTRACT

Thymic Hyperplasia With Occult Ectopic ACTH Syndrome
Ryan et al.
Arch Intern Med 1986;146:2411-2414.
ABSTRACT

The Conundrum of Cushing's Syndrome
Mellinger
Arch Intern Med 1986;146:858-860.
ABSTRACT

| | |