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Antihypertensive Drug Therapy Withdrawal in a General Population
Michael H. Alderman, MD;
Toni K. Davis, MS;
Linda M. Gerber, PhD;
Marion Robb, RN
Arch Intern Med. 1986;146(7):1309-1311.
Abstract
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• To determine the fraction of all hypertensives who can be successfully withdrawn from antihypertensive medication, a study was conducted of a patient group originally drawn from a screened population of union members. Of 157 patients, 88 (56.1%) met preestablished blood pressure criteria for drug interruption, and 66 (75%) actually had medication withdrawn. Of these 66 patients, 69.8% and 54.5% followed up for one and two years, respectively, remained normotensive. Patients requiring reintroduction of antihypertensive therapy were distinguished from those remaining drug free by increased systolic blood pressure (141.4±13.2 vs 131.6 ± 8.6 mm Hg) after one month. Extrapolation of the finding that 28% of the study population remained normotensive one year after drug therapy withdrawal suggests the possibility that as many as 5 million Americans currently taking antihypertensive drugs could have therapy interrupted for at least one year and thus avoid both the hazards and costs of drug therapy.
(Arch Intern Med 1986;146:1309-1311)
Author Affiliations
From the Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY (Dr Alderman and Ms Robb); National Center for Health Education, New York (Ms Davis); and the Office of Epidemiology, Nassau County Department of Health, Mineola, NY (Dr Gerber).
Footnotes
Accepted for publication Oct 23, 1985.
Read in part before the annual meeting of the American Federation for Clinical Research, Washington, DC, May 6, 1984.
Reprint requests to Department of Epidemiology, Montefiore Medical Center, 111 E 210th St, Bronx, NY 10467 (Dr Alderman).
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