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Mark H. Gross, PharmD; William J. Fulkerson, MD; Joseph O. Moore, MD

Arch Intern Med. 1986;146(8):1587-1588.

Abstract
• Three patients had severe amphotericin B—induced rigors refractory to conventional prophylactic measures. Rigors improved or disappeared when dantrolene sodium was given prophylactically or during an episode. These observations suggest that dantrolene is useful as an alternative or adjuvant agent for severe rigors associated with amphotericin B infusion.

(Arch Intern Med 1986;146:1587-1588)

Author Affiliations
From the Departments of Pharmacy (Dr Gross) and Medicine (Drs Fulkerson and Moore), Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Dec 30, 1985.

Reprints not available.

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