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Low-Dose Autologous In Vitro Opsonized ErythrocytesRadioimmune Method and Autologous Opsonized Erythrocytes for Refractory Autoimmune Thrombocytopenic Purpura in Adults
Raúl Ambriz, MD;
Rodrigo Muñóz, MD;
Javier Pizzuto, MD, FACP;
Elisa Quintanar;
Manuel Morales, MD, FACP;
Agustin Avilés, MD
Arch Intern Med. 1987;147(1):105-108.
Abstract
• Adult patients with chronic autoimmune thrombocytopenic purpura (ATP), which proved refractory to various treatments, received a single dose of autologous in vitro opsonized erythrocytes with 100 µg of anti-D IgG. In 1983, 30 of these patients were treated with autologous erythrocytes that had been opsonized and labeled with 25 mCi (740 MBq) of technetium Tc 99m; this treatment was designated as the radioimmune method. Favorable responses were noted in 36% of patients so treated. In 1985, another group of 16 patients with refractory ATP received therapy with autologous opsonized erythrocytes (AOPE) and 55% of these patients showed favorable responses. Five (17%) of the patients treated using the radioimmune method attained a complete, long-term (>35 months) remission of their ATP, and five (31%) of the patients treated using AOPE remained in complete remission over 270 days after cessation of therapy. Major complications were not seen. We concluded that the interaction of macrophages with low-dose AOPE is a successful therapeutic approach in ATP refractory to standard treatment.
(Arch Intern Med 1987;147:105-108)
Author Affiliations
From the Departments of Hematology (Drs Ambriz, Pizzuto, Morales, and Aviles), Nuclear Medicine (Dr Muñóz), and Immunology (Ms Quintanar), General Hospital and Central Blood Bank, National Medical Center, Mexico City.
Footnotes
Accepted for publication April 7, 1986.
Presented in part at the 26th annual meeting of the American Society of Hematology, Miami Beach, Fla, Dec 3, 1984.
Reprint requests to the Department of Hematology, General Hospital and Central Blood Bank, National Medical Center, IMSS, Mexico City 06720, Mexico (Dr Ambriz).
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