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A Review of the Epidemiologic Evidence in Humans

Graham A. Colditz, MD; Meir J. Stampfer, MD; Walter C. Willett, MD

Arch Intern Med. 1987;147(1):157-160.

Abstract
• We reviewed the human epidemiologic studies of the possible protective effect against lung cancer of various dietary constituents, including preformed vitamin A, carotene, vitamin E, selenium, and vitamin C. Beta carotene has strong potential as a protective agent, though constituents of green and yellow vegetables other than carotene may account for the reduced cancer incidence observed in many studies. Selenium also deserves attention as a potential chemopreventive nutrient, though data are limited. Data on vitamin E are sparse and inconclusive, and there is little evidence that vitamin C provides protection against human lung cancer. It is likely that cessation of cigarette smoking would have a far greater influence on reducing lung cancer incidence than any known dietary modification.

(Arch Intern Med 1987;147:157-160)

Author Affiliations
From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (Drs Colditz, Stampfer, and Willett), and the Department of Epidemiology, Harvard School of Public Health (Dr Willett), Boston.

Footnotes
Accepted for publication July 21, 1986.

Reprint requests to Channing Laboratory, 180 Longwood Ave, Boston, MA 02215 (Dr Colditz).

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