This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (108)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Improvement in Patients With Associated Gastroesophageal Reflux

Philip C. Harper, MD; Arthur Bergner, MD; Michael D. Kaye, DM, FRCP

Arch Intern Med. 1987;147(1):56-60.

Abstract
• Fifteen patients with both nonallergic asthma and symptomatic gastroesophageal reflux were studied before and after an eight-week period of vigorous antireflux therapy, which included ranitidine hydrochloride, 150 mg twice a day. Pulmonary and esophageal symptoms were recorded on daily diary cards. Therapy was associated with prompt amelioration of reflux symptoms and with a less dramatic and more delayed improvement in pulmonary symptoms. Objectively, esophageal erosions healed completely in eight of the ten patients who had them at the beginning of the trial, and pulmonary function measurements improved significantly. Intraesophageal infusions of physiologic saline and 0.1N hydrochloric acid in patients and healthy controls did not significantly alter pulmonary function, as measured by standard spirometry. There is a subset of patients in whom bronchoconstriction is triggered by gastroesophageal reflux. Treatment of reflux in such patients may improve their asthma.

(Arch Intern Med 1987;147:56-60)

Author Affiliations
From the Department of Medicine, College of Medicine, University of Vermont, Burlington.

Footnotes
Accepted for publication May 21, 1986.

Reprint requests to Given Bldg, Room C307, College of Medicine, University of Vermont, Burlington, VT 05405 (Dr Kaye).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acid aspiration-induced airways hyperresponsiveness in mice
Allen et al.
J. Appl. Physiol. 2009;107:1763-1770.
ABSTRACT | FULL TEXT  

Gastro-oesophageal reflux and bronchial asthma: current status and future directions
Mathew et al.
Postgrad. Med. J. 2004;80:701-705.
ABSTRACT | FULL TEXT  

Sleep-Related Breathing Disorders : Is It All About Apnea?
Orr
Chest 2002;121:8-11.
FULL TEXT  

Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review
Coughlan et al.
Thorax 2001;56:198-204.
ABSTRACT | FULL TEXT  

Asthma and Gastroesophageal Reflux Disease : The Truth Is Difficult to Define
Richter
Chest 1999;116:1150-1152.
FULL TEXT  

Gastroesophageal Reflux in Asthmatics: A Double-Blind, Placebo-Controlled Crossover Study With Omeprazole
Kiljander et al.
Chest 1999;116:1257-1264.
ABSTRACT | FULL TEXT  

The Effects of Antireflux Surgery on Asthmatics With Gastroesophageal Reflux
Field et al.
Chest 1999;116:766-774.
ABSTRACT | FULL TEXT  

A Critical Review of the Studies of the Effects of Simulated or Real Gastroesophageal Reflux on Pulmonary Function in Asthmatic Adults
Field
Chest 1999;115:848-856.
ABSTRACT | FULL TEXT  

Gastro-oesophageal reflux related cough and its response to laparoscopic fundoplication
Allen and Anvari
Thorax 1998;53:963-968.
ABSTRACT | FULL TEXT  

Gastroesophageal Reflux Disease and Asthma: Diagnosis and Management
Simpson
Arch Intern Med 1995;155:798-803.
ABSTRACT  

The Effects of Inhaled Albuterol and Oral Theophylline on Gastroesophageal Reflux in Patients With Gastroesophageal Reflux Disease and Obstructive Lung Disease
Ruzkowski et al.
Arch Intern Med 1992;152:783-785.
ABSTRACT  

Exercise-Induced Asthma
Kavanaugh
ANN INTERN MED 1990;113:170-170.
ABSTRACT  

Treatment of Gastroesophageal Reflux-Induced Asthma: Steroids, {beta}2-Stimulants, and H2-Blockers
Umeki
Arch Intern Med 1987;147:997-997.
ABSTRACT  

Treatment of Gastroesophageal Reflux-Induced Asthma: Steroids, {beta}2-Stimulants, and H2-Blockers-Reply
Maddox
Arch Intern Med 1987;147:997-997.
ABSTRACT