 |
|
Effects of Sickle Cell Anemia on Conjunctival Oxygen Tension and Temperature
Sherwin J. Isenberg, MD;
William E. McRee, MD;
Michael S. Jedrzynski, MD;
Steven N. Gange, MD;
Sherri L. Gange, MD
Arch Intern Med. 1987;147(1):67-69.
Abstract
• Because conjunctival vessels are affected by sickle cell disease, we wanted to see if conjunctival Po2 (partial oxygen tension) and temperature were also affected and if these measurements could aid in managing these patients. Conjunctival Po2 and temperature in 23 asmptomatic homozygous patients with sickle cell anemia did not differ significantly from those in age-matched controls. However, 12 subjects in painful sickle cell crisis had a significantly lower conjunctival Po2 than before crisis despite no significant change in hematocrit and conjunctival temperature. Supplemental oxygen therapy significantly increased conjunctival Po2. When supplemental oxygen was removed, conjunctival Po2 decreased to the admission level despite clinical improvement. This finding supports the use of supplemental oxygen in treating crisis. Measuring conjunctival Po2 can give clinicians an assessment of the effect of sickle cell disease on a peripheral capillary bed and may provide the first objective method to reliably diagnose acute painful sickle cell crisis.
(Arch Intern Med 1987;147:67-69)
Author Affiliations
From the Department of Ophthalmology, UCLA School of Medicine, Los Angeles; Harbor—UCLA Medical Center, Torrance, Calif; and the Jules Stein Eye Institute, Los Angeles.
Footnotes
Accepted for publication May 27, 1986.
Reprint requests to Department of Ophthalmology, Harbor—UCLA Medical Center, 1000 W Carson St, Box 6, Torrance, CA 90509 (Dr Isenberg).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
|
