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B-Cell Activation and Immunoregulation in End-Stage Renal Disease Patients Receiving Hemodialysis
Jana Raskova, MD;
Ibrahim Ghobrial, MSc;
Debra K. Czerwinski;
Stephen M. Shea, MD;
Robert P. Eisinger, MD;
Karel Raska, Jr, MD, PhD
Arch Intern Med. 1987;147(1):89-93.
Abstract
• B-lymphocyte functions were studied in peripheral blood mononuclear cells of end-stage renal disease patients undergoing intermittent hemodialysis for longer than two years. T-cell—dependent B lymphocyte proliferation after pokeweed mitogen stimulation was low in half of the hemodialyzed patients. T cell—independent B cell response to Staphylococcus aureus, Cowan I, was also significantly reduced. Spontaneous production of immunoglobulin in cultures of peripheral blood mononuclear cells of uremic patients was comparable with that of healthy controls, but pokeweed mitogen—stimulated antibody secretion was significantly reduced with cells from patients undergoing hemodialysis. Helper T-cell functions in B-cell activation were also qualitatively deficient in uremic patients. It is concluded that B-cell activation and immunoregulation is defective in patients undergoing long-term hemodialysis.
(Arch Intern Med 1987;147:89-93)
Author Affiliations
From the Departments of Pathology (Drs Raskova, Shea, and Raska and Mr Ghobrial and Ms Czerwinski) and Medicine (Dr Eisinger), University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway; and Middlesex General-University Hospital (Drs Raskova, Shea, Eisinger, and Raska), New Brunswick, NJ.
Footnotes
Accepted for publication April 23, 1986.
Reprint requests to Department of Pathology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 (Dr Raska).
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