This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (271)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Rena R. Wing, PhD; Randi Koeske, PhD; Leonard H. Epstein, PhD; Mary Patricia Nowalk, MSHyg; William Gooding, MS; Dorothy Becker, MBBCh

Arch Intern Med. 1987;147(10):1749-1753.

Abstract
• Since most obese patients with type II diabetes are unable to achieve ideal body weight, this study examined whether more modest weight losses would provide a long-term benefit. Type II diabetic patients (N =114) were treated in a behavioral weight control program and followed up for one year. Weight loss was significantly correlated with improvements in glycosylated hemoglobin values at posttreatment (r=.55) and one year (r=.51). Patients who lost more than 6.9 kg or had more than 5% reduction in body weight had significant improvements in glycosylated hemoglobin values at one year, while patients losing less weight had nonsignificant changes and those gaining weight had significant worsening. Thus, modest weight loss can have a long-term impact on glycemic control. However, the improvement in glycemic control for a given weight loss was greater initially than at one year, suggesting that energy restriction, in addition to weight loss, may contribute to initial improvement. Neither percent overweight nor diabetes treatment affected weight loss.

(Arch Intern Med 1987;147:1749-1753)

Author Affiliations
From the University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication June 23, 1987.

Reprint requests to Western Psychiatric Institute and Clinic, 3811O'Hara St, Pittsburgh, PA 15213 (Dr Wing).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity During Calorie Restriction and Weight Stabilization
Capel et al.
Diabetes 2009;58:1558-1567.
ABSTRACT | FULL TEXT  

Review: Bariatric surgery: to treat diabesity
Flatt et al.
British Journal of Diabetes & Vascular Disease 2009;9:103-107.
ABSTRACT  

The Metabolic Syndrome
Cornier et al.
Endocr. Rev. 2008;29:777-822.
ABSTRACT | FULL TEXT  

Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes
Laferrere et al.
J. Clin. Endocrinol. Metab. 2008;93:2479-2485.
ABSTRACT | FULL TEXT  

Themed Review: Lifestyle Interventions Across the Continuum of Type 2 Diabetes: Reducing the Risks of Diabetes
Franz
AMERICAN JOURNAL OF LIFESTYLE MEDICINE 2007;1:327-334.
ABSTRACT  

Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes
Toledo et al.
Diabetes 2007;56:2142-2147.
ABSTRACT | FULL TEXT  

The Dilemma of Weight Loss in Diabetes
Franz
Diabetes Spectr. 2007;20:133-136.
FULL TEXT  

Motivational Interviewing Improves Weight Loss in Women With Type 2 Diabetes
West et al.
Diabetes Care 2007;30:1081-1087.
ABSTRACT | FULL TEXT  

Insulin Treatment and the Problem of Weight Gain in Type 2 Diabetes
Carver
The Diabetes Educator 2006;32:910-917.
ABSTRACT | FULL TEXT  

Effect of Weight Loss and Nutritional Intervention on Arterial Stiffness in Type 2 Diabetes
Barinas-Mitchell et al.
Diabetes Care 2006;29:2218-2222.
ABSTRACT | FULL TEXT  

What is the relationship between risk factor reduction and degree of weight loss?
Van Gaal et al.
Eur Heart J Suppl 2005;7:L21-L26.
ABSTRACT | FULL TEXT  

Moderate Caloric Restriction, But Not Physiological Hyperleptinemia Per Se, Enhances Mitochondrial Oxidative Capacity in Rat Liver and Skeletal Muscle--Tissue-Specific Impact on Tissue Triglyceride Content and AKT Activation
Barazzoni et al.
Endocrinology 2005;146:2098-2106.
ABSTRACT | FULL TEXT  

Overweight and obesity and weight change in middle aged men: impact on cardiovascular disease and diabetes
Wannamethee et al.
J. Epidemiol. Community Health 2005;59:134-139.
ABSTRACT | FULL TEXT  

Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation
Klein et al.
Circulation 2004;110:2952-2967.
ABSTRACT | FULL TEXT  

Pounds Off With Empowerment (POWER): A Clinical Trial of Weight Management Strategies for Black and White Adults With Diabetes Who Live in Medically Underserved Rural Communities
Mayer-Davis et al.
AJPH 2004;94:1736-1742.
ABSTRACT | FULL TEXT  

Diagnosis and Treatment of Obesity in Adults: An Applied Evidence-Based Review
Orzano and Scott
J Am Board Fam Med 2004;17:359-369.
ABSTRACT | FULL TEXT  

Diet, Insulin Resistance, and Obesity: Zoning in on Data for Atkins Dieters Living in South Beach
Lara-Castro and Garvey
J. Clin. Endocrinol. Metab. 2004;89:4197-4205.
ABSTRACT | FULL TEXT  

Efficacy of Pharmacotherapy for Weight Loss in Adults With Type 2 Diabetes Mellitus: A Meta-analysis
Norris et al.
Arch Intern Med 2004;164:1395-1404.
ABSTRACT | FULL TEXT  

Obesity treatment: the key to managing the type 2 diabetes timebomb?
Wilding
British Journal of Diabetes & Vascular Disease 2004;4:217-219.
 

Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes
Kelley et al.
Diabetes Care 2004;27:33-40.
ABSTRACT | FULL TEXT  

Sugars and starch in the nutritional management of diabetes mellitus
Kelley
Am. J. Clin. Nutr. 2003;78:858S-864.
ABSTRACT | FULL TEXT  

The Impact of Bariatric Surgery on Severely Obese Patients With Diabetes
Eisenberg and Bell
Diabetes Spectr. 2003;16:240-245.
ABSTRACT | FULL TEXT  

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study
Uusitupa et al.
Diabetes 2003;52:2532-2538.
ABSTRACT | FULL TEXT  

One-Year Outcome of a Combination of Weight Loss Therapies for Subjects With Type 2 Diabetes: A randomized trial
Redmon et al.
Diabetes Care 2003;26:2505-2511.
ABSTRACT | FULL TEXT  

Battling Insulin Resistance in Elderly Obese People With Type 2 Diabetes: Bring on the heavy weights
Willey and Singh
Diabetes Care 2003;26:1580-1588.
ABSTRACT | FULL TEXT  

Treatment of Obesity: An Overview
Fabricatore and Wadden
Clin. Diabetes 2003;21:67-72.
ABSTRACT | FULL TEXT  

Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines
Mooradian
Arch Intern Med 2003;163:33-40.
ABSTRACT | FULL TEXT  

The investigation and management of obesity
Labib
J. Clin. Pathol. 2003;56:17-25.
ABSTRACT | FULL TEXT  

Evolution of diabetes medical nutrition therapy
Franz et al.
Postgrad. Med. J. 2003;79:30-35.
ABSTRACT | FULL TEXT  

Anesthetic Considerations for Bariatric Surgery
Ogunnaike et al.
Anesth. Analg. 2002;95:1793-1805.
FULL TEXT  

The Effect of Orlistat-Induced Weight Loss, Without Concomitant Hypocaloric Diet, on Cardiovascular Risk Factors and Insulin Sensitivity in Young Obese Chinese Subjects With or Without Type 2 Diabetes
Tong et al.
Arch Intern Med 2002;162:2428-2435.
ABSTRACT | FULL TEXT  

2002 Diabetes Nutrition Recommendations: Grading the Evidence
Franz
The Diabetes Educator 2002;28:756-766.
 

Effect of Orlistat in Overweight and Obese Patients With Type 2 Diabetes Treated With Metformin
Miles et al.
Diabetes Care 2002;25:1123-1128.
ABSTRACT | FULL TEXT  

Evidence-Based Trends for Achieving Weight Loss and Increased Physical Activity: Applications for Diabetes Prevention and Treatment
Delahanty
Diabetes Spectr. 2002;15:183-189.
ABSTRACT | FULL TEXT  

Clinical Efficacy of Orlistat Therapy in Overweight and Obese Patients With Insulin-Treated Type 2 Diabetes: A 1-year randomized controlled trial
Kelley et al.
Diabetes Care 2002;25:1033-1041.
ABSTRACT | FULL TEXT  

Culturally Competent Diabetes Self-Management Education for Mexican Americans: The Starr County Border Health Initiative
Brown et al.
Diabetes Care 2002;25:259-268.
ABSTRACT | FULL TEXT  

Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications
Franz et al.
Diabetes Care 2002;25:148-198.
FULL TEXT  

Review: Implications of obesity for diabetes and coronary heart disease in clinical practice
Pinkney
British Journal of Diabetes & Vascular Disease 2001;1:103-106.
ABSTRACT  

Effects of Sibutramine in Obese Female Subjects With Type 2 Diabetes and Poor Blood Glucose Control
Gokcel et al.
Diabetes Care 2001;24:1957-1960.
ABSTRACT | FULL TEXT  

Weight Loss, Diets, and Supplements: Does Anything Work?
Boucher et al.
Diabetes Spectr. 2001;14:169-175.
FULL TEXT  

Longitudinal Changes in Body Fat in African American and Caucasian Children: Influence of Fasting Insulin and Insulin Sensitivity
Johnson et al.
J. Clin. Endocrinol. Metab. 2001;86:3182-3187.
ABSTRACT | FULL TEXT  

Does "Diet" Fail?
Franz et al.
The Diabetes Educator 2001;27:563-570.
 

Skeletal Muscle Triglyceride: An aspect of regional adiposity and insulin resistance
Kelley and Goodpaster
Diabetes Care 2001;24:933-941.
ABSTRACT | FULL TEXT  

Diabetes Prevention: How About NOW?
Levetan
Clin. Diabetes 2001;19:34-38.
FULL TEXT  

Behavioral Science Research in Diabetes: Lifestyle changes related to obesity, eating behavior, and physical activity
Wing et al.
Diabetes Care 2001;24:117-123.
ABSTRACT | FULL TEXT  

Pathophysiology and Pharmacological Treatment of Insulin Resistance
Matthaei et al.
Endocr. Rev. 2000;21:585-618.
ABSTRACT | FULL TEXT  

Healthy Lifestyles: A Pilot Program to Influence Behavior Change
Jacobs and Felt
The Diabetes Educator 2000;26:230-244.
 

Benefits and risks of antiobesity agents
Anderson and Konz
Am. J. Clin. Nutr. 2000;71 :844-845.
FULL TEXT  

Continuity of Care, Informed Consent, and Fiduciary Responsibilities in For-Profit Managed Care Systems
Holleman et al.
Arch Fam Med 2000;9:21-25.
ABSTRACT | FULL TEXT  

Weight Loss Due to Energy Restriction Suppresses Cholesterol Biosynthesis in Overweight, Mildly Hypercholesterolemic Men
Di Buono et al.
J. Nutr. 1999;129:1545-1548.
ABSTRACT | FULL TEXT  

Why and how should adults lose weight?
DTB 1998;36:89-92.
ABSTRACT | FULL TEXT  

Prediction of Glucose Response to Weight Loss in Patients With Non-Insulin-Dependent Diabetes Mellitus
Watts et al.
Arch Intern Med 1990;150:803-806.
ABSTRACT