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Report of a Case and Review of the Literature

Antonis S. Manolis, MD; Therese Tordjman, MD; Keith D. Mack, RN, BSN; N. A. Mark Estes III, MD

Arch Intern Med. 1987;147(10):1805-1809.

Abstract
• Atypical manifestations of pulmonary toxicity and previously unreported autonomic nervous system dysfunction complicating amiodarone therapy were observed in a patient being treated for sustained ventricular tachycardia. Pulmonary and hepatic nodules on computed tomographic scan masquerading as metastatic carcinoma were initially noted. Focal infiltrates and a large left pleural effusion mimicking infection, malignant neoplasm, or collagen vascular disease became manifest at a later stage. Autonomic dysfunction presented as incapacitating orthostatic hypotension and persisted for six weeks after amiodarone withdrawal. The pleuropulmonary toxic effects were reversible on discontinuation of amiodarone therapy, and resolution was hastened by short-course steroid treatment.

(Arch Intern Med 1987;147:1805-1809)

Author Affiliations
From the Cardiac Electrophysiology Laboratory, Division of Cardiology, Tufts/New England Medical Center, Boston.

Footnotes
Accepted for publication July 15, 1987.

Reprint requests to Box 98, New England Medical Center, 750 Washington St, Boston, MA 02111 (Dr Estes).

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