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Richard L. Harris, MD; Daniel M. Musher, MD; Kim Bloom, MD; Joe Gathe, MD; Lawrence Rice, MD; Barrett Sugarman, MD; Temple W. Williams, Jr, MD; Edward J. Young, MD

Arch Intern Med. 1987;147(11):1895-1906.

Abstract
• The clinical manifestations of sepsis may be flagrant or subtle. Awareness of the signs and symptoms of sepsis allows early recognition and prompt, appropriate management. The clinical presentation, relative frequency, and current patho-physiologic understanding of the manifestations of sepsis are reviewed. Special emphasis is placed on the cardiopulmonary manifestations, which are examined in a temporal sequence of preshock, early shock, and late shock states. While therapy for the underlying infection (such as antibiotics and drainage of abscesses) is often sufficient, therapy for the specific manifestations of sepsis may also be necessary. Guidelines for therapy for these manifestations of sepsis are given.

(Arch Intern Med 1987;147:1895-1906)

Author Affiliations
From the Department of Medicine, Baylor College of Medicine, Houston (Drs Harris, Musher, Bloom, Gathe, Rice, Williams, and Young); and the Department of Medicine, Michigan State University, East Lansing (Dr Sugarman).

Footnotes
Accepted for publication July 16, 1987.

Reprint requests to Infectious Disease Laboratory, Methodist Hospital, MS 910, 6565 Fannin, Houston, TX 77030 (Dr Harris).

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