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Jesse M. Berkowitz, MD; Paula R. Rogenes, PhD; Jeffrey T. Sharp, MS; Christopher W. Warner, PhD

Arch Intern Med. 1987;147(12):2137-2139.

Abstract
• A randomized, double-blind, placebo-controlled study examined whether concomitant administration of ranitidine could protect against the gastroduodenal mucosal damage associated with long-term aspirin therapy in healthy men. Twenty-four subjects received ranitidine (150 mg twice daily) plus aspirin (650 mg four times daily), and 19 received placebo twice daily plus aspirin (650 mg four times daily) for four weeks. Gastric injury and duodenal injury were assessed separately according to a numerical rating scale for incidence and severity of lesions observed during endoscopic examinations at baseline and after four weeks of treatment. The ranitidine/aspirin group had significantly less mucosal damage in the stomach and duodenum than the placebo/aspirin group. Mean serum salicylate levels were similar between treatment groups after two and four weeks of aspirin therapy. Therefore, the protective effect of ranitidine was achieved with no compromise in salicylate absorption.

(Arch Intern Med 1987;147:2137-2139)

Author Affiliations
From the Department of Medicine, Mercy Hospital, Rockville Centre, NY, and the School of Medicine, State University of New York at Stony Brook (Dr Berkowitz), and Glaxo Inc, Research Triangle Park, NC (Drs Rogenes and Warner and Mr Sharp).

Footnotes
Accepted for publication Sept 8, 1987.

Reprint requests to the Department of Medicine, Mercy Hospital, Rockville Centre, NY 11570 (Dr Berkowitz).

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