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Postpartum Lymphocytic ThyroiditisPrevalence, Clinical Course, and Long-term Follow-up
Thomas F. Nikolai, MD;
Susan L. Turney, MD;
Ronald C. Roberts, PhD
Arch Intern Med. 1987;147(2):221-224.
Abstract
• A group of 238 women were surveyed for thyroid disease at six and 12 weeks post partum. Twenty-seven (11.3%) of 238 entered into the study were found to have thyroid disease. Fifteen (56%) of 27 had positive microsomal hemagglutinin antibody titers. A spectrum of thyroid disease was found: persistent hypothyroidism (two patients), transient thyrotoxicosis followed by persistent hypothyroidism (one) or transient hypothyroidism (three), euthyroid goiter (five), transient thyrotoxicosis (seven), transient hypothyroidism (three), high-normal thyroxine levels (five), and low-normal thyroxine levels (one). All nine patients who underwent biopsy had active lymphocytic thyroiditis. Three-year follow-up of 25 of the 27 affected individuals revealed that 12 (48%) still had thyroid disease. This study demonstrates that there is a high incidence of postpartum thyroid disease, usually of a transient nature, and that only about one fourth of the cases are detected or clinically obvious.
(Arch Intern Med 1987;147:221-224)
Author Affiliations
From the Marshfield (Wis) Clinic and the Marshfield Medical Research Foundation.
Footnotes
Accepted for publication July 21, 1986.
Reprint requests to Marshfield Clinic, 1000 Oak Ave, Marshfield, WI 54449 (Dr Nikolai).
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