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Thomas E. Lad, MD; Howard M. Mishoulam, MD; Daniel H. Shevrin, MD; Lawrence J. Kukla, MD; Edith C. Abramson, MD; Subhash C. Kukreja, MD

Arch Intern Med. 1987;147(2):329-332.

Abstract
• Cisplatin (cis-platinum) has been shown to lower cancerassociated humoral hypercalcemia in an animal model and to inhibit bone resorption in vitro. This prospective study was designed to evaluate the efficacy of cisplatin in treating cancer-associated hypercalcemia in humans. Thirteen patients with severe hypercalcemia refractory to rehydration were treated with a 24-hour infusion of cisplatin, 100 mg/m². Serial measurements of serum calcium and tumor size were made following cisplatin treatment and compared with pretreatment values. Nine patients (69%) achieved normocalcemia after treatment with cisplatin; and mean duration of benefit was 38 days in these patients. No reduction in tumor size was seen. All patients died of progressive cancer. We conclude that cisplatin can control malignant hypercalcemia for relatively long periods, and that its mechanism of action is not due to a reduction in tumor size.

(Arch Intern Med 1987;147:329-332)

Author Affiliations
From the Sections of Medical Oncology (Drs Lad, Mishoulam, Shevrin, and Kukla) and Endocrinology (Drs Abramson and Kukreja), Department of Medicine, West Side Veterans Administration and University of Illinois Hospitals, University of Illinois College of Medicine, Chicago.

Footnotes
Accepted for publication July 1, 1986.

Reprint requests to Medical Oncology Section (MP 111), Veterans Administration West Side Medical Center, PO Box 8195, Chicago, IL 60680 (Dr Lad).

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