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Rebound Hypertension Following Abrupt Cessation of Clonidine and MetoprololTreatment With Labetalol
Jawahar L. Mehta, MD;
Larry M. Lopez, PharmD
Arch Intern Med. 1987;147(2):389-390.
Abstract
• Abrupt withdrawal of adrenergic blockers in a hypertensive subject may result In acute hypertensive crisis. This crisis results from marked increase in adrenergic discharge and upregulation of adrenoceptors. In a patient with hypertensive crisis following abrupt cessation of clonidine hydrochloride and metoprolol tartrate, intravenous administration of labetalol hydrochloride rapidly reduced blood pressure and heart rate to precrisis levels. The patient was subsequently maintained in a normotensive state by continued oral use of labetalol. This case study demonstrates that  - and β-blocking activities of labetalol may be particularly beneficial in a hyperadrenergic state following abrupt withdrawal of adrenergic blockers.
(Arch Intern Med 1987;147:389-390)
Author Affiliations
From the Veterans Administration Medical Center (Dr Mehta) and the University of Florida College of Medicine and Pharmacy, Departments of Medicine (Dr Mehta) and Pharmacy Practice (Dr Lopez), Gainesville.
Footnotes
Accepted for publication July 9, 1986.
Reprint requests to Department of Medicine, University of Florida, Box J-277, J. Hillis Miller Health Center, Gainesville, FL 32610 (Dr Mehta).
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