This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (25)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Prospective Evaluation

LTC John B. Copley, MC, USA; MAJ James A. Hasbargen, MC, USA

Arch Intern Med. 1987;147(3):434-437.

Abstract
• Evaluation of the patient with isolated hematuria is often problematic. Sixty-five patients with this entity were studied prospectively with renal biopsy; serum IgA levels, skin biopsy for IgA immunofluorescence, and HLA typing were also studied in most patients. Previously, all patients had had a noncontributory history and physical examination, normal results of structural evaluation, serologic and clotting studies, and proteinuria of less than 1000 mg/d (<1 g/d). Seventy-eight percent were found to have abnormal renal biopsy results and were divisible into two patient groups: those with IgA nephropathy (49%, 32/65) and those with multiple nonspecific abnormalities (29%, 19/65). Ancillary testing, demographic data, and clinical data, other than abnormal amounts of proteinuria, were not distinguishable between these groups and patients with normal renal biopsy results (22%, 14/65). Etiologic differentiation of the hematuria was possible only by renal biopsy. At present, renal biopsy in this group of patients makes no difference therapeutically or, probably, prognostically. It should not, therefore, be considered necessary for routine management of asymptomatic hematuria.

(Arch Intern Med 1987;147:434-437)

Author Affiliations
From the Nephrology Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Tex (Dr Copley), and the Nephrology Service, Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colo (Dr Hasbargen).

Footnotes
Accepted for publication Aug 21, 1986.

Read in part at the 16th annual meeting of the American Society of Nephrology, Washington, DC, Dec 4, 1983.

The views expressed herein are those of the authors and do not necessarily reflect the views of the US Army or the Department of Defense.

Reprint requests to Nephrology Service (HSHE-MDN), Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200 (Dr Copley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Evaluation of Hematuria in Adults
Sutton
JAMA 1990;263:2475-2480.
ABSTRACT  

Dipstick Urinalysis Screening of Asymptomatic Adults for Urinary Tract Disorders: I. Hematuria and Proteinuria
Woolhandler et al.
JAMA 1989;262:1214-1219.
ABSTRACT  

Establishing the Diagnosis of Benign Familial Hematuria: The Importance of Examining the Urine Sediment of Family Members
Blumenthal et al.
JAMA 1988;259:2263-2266.
ABSTRACT