This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (29)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Mary A. O'Neil-Cutting, SM; William H. Crosby, MD

Arch Intern Med. 1987;147(3):489-491.

Abstract
• Using a small-dose iron tolerance test (ITT) in mildly irondeficient healthy adults, we have examined the phenomenon of mucosal block. First proposed and demonstrated by Hahn et al with radioiron, "mucosal block" describes diminished avidity for iron of the intestinal mucosa following an orally administered blocking dose. In the ITT, the index of absorption is an increase in plasma iron concentration, rather than retained radioactivity. The absorption of a blocked 10-mg test dose of iron was compared with that of a 10-mg control dose given to the same subject. Both 60- and 30-mg blocking doses of iron resulted in diminished absorption of the test dose. The refractory state of the intestine lasted as long as 24 hours.

(Arch Intern Med 1987;147:489-491)

Author Affiliations
From the Department of Hematology, Division of Medicine, Walter Reed Army Institute of Research, Washington, DC. Dr Crosby is presently with the Chapman Regional Cancer Center, Joplin, Mo.

Footnotes
Accepted for publication May 16, 1986.

Reprint requests to Chapman Regional Cancer Center, PO Box 2644, Joplin, MO 64803 (Dr Crosby).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods
Domellof et al.
Am. J. Clin. Nutr. 2002;76:198-204.
ABSTRACT | FULL TEXT  

Iron homeostasis: new tales from the crypt
Roy and Enns
Blood 2000;96:4020-4027.
ABSTRACT | FULL TEXT  

Daily Iron Supplementation Is More Effective than Twice Weekly Iron Supplementation in Pregnant Women in Pakistan in a Randomized Double-Blind Clinical Trial
Mumtaz et al.
J. Nutr. 2000;130:2697-2702.
ABSTRACT | FULL TEXT  

Effect of iron-, iodine-, and ß-carotene–fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial
van Stuijvenberg et al.
Am. J. Clin. Nutr. 1999;69:497-503.
ABSTRACT | FULL TEXT