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  Vol. 147 No. 4, April 1987 TABLE OF CONTENTS
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Cardioembolic Stroke, Early Anticoagulation, and Brain Hemorrhage

Cerebral Embolism Study Group

Arch Intern Med. 1987;147(4):636-640.


Abstract



• Brain hemorrhage is a feared complication of early anticoagulation therapy in patients with cardioembolic brain infarction. We describe nine patients with cardioembolic stroke who experienced clinical deterioration associated with computed tomography—documented hemorrhagic transformation. The clinical features of these nine patients combined with 15 previously reported cases were analyzed to determine factors associated with hemorrhagic worsening. Patient age, embolic source, and intensity of anticoagulation were not associated with hemorrhagic worsening. Large infarct size and initiation of anticoagulation after early (<12 hours) computed tomography were associated with hemorrhagic transformation and clinical worsening in patients who received anticoagulation therapy.

(Arch Intern Med 1987;147:636-640)



Footnotes



Accepted for publication Aug 18, 1986.

A complete listing of the members who participated in this research study appears at the end of this article.

Reprint requests to Department of Medicine (Neurology), University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78284 (Robert G. Hart, MD).



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