This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (28)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effect on Esophageal and Gastric Motility Abnormalities

David A. Johnson, MD; Walter E. Drane, MD; James Curran, MD; Stanley B. Benjamin, MD; Sarkis J. Chobanian, MD; Kastytis Karvelis, MD; Edward L. Cattau, Jr, MD

Arch Intern Med. 1987;147(9):1597-1601.

Abstract
• Twelve patients with progressive systemic sclerosis (four with CREST [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia] variant) underwent systematic evaluation to assess the esophagogastric effects of metoclopramide hydrochloride in this patient population. Esophageal manometry, esophageal radionuclide scintigraphy, solid-phase gastric emptying, and 24-hour esophageal pH monitoring were performed in all patients with and without metoclopramide. Metoclopramide improved lower esophageal sphincter pressure and reduced the gastric emptying delay and gastroesophageal reflux in most patients but had a less consistent effect improving esophageal transit or esophageal body pressures. Metoclopramide should be strongly considered in the pharmacologic approach to the gastroesophageal reflux-related complications of this disease.

(Arch Intern Med 1987;147:1597-1601)

Author Affiliations
From the Division of Gastroenterology, Departments of Medicine (Drs Johnson and Chobanian), Nuclear Medicine (Drs Drane and Karvelis), and Rheumatology (Dr Curran), Naval Hospital, the Division of Gastroenterology, Department of Medicine, Uniformed Services of the Health Sciences (Drs Johnson and Chobanian), Bethesda, Md; and the Division of Gastroenterology, Department of Medicine, Georgetown University Hospital, Washington, DC (Drs Benjamin and Cattau).

Footnotes
Accepted for publication May 13, 1987.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official policy or as reflecting the views of the Department of the Navy or the Department of Defense.

Reprint requests to Naval Hospital, Box 247, Bethesda, MD 20814-5011 (Dr Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pulmonary Disease in Progressive Systemic Sclerosis: A Complication of Gastroesophageal Reflux and Occult Aspiration?
Johnson et al.
Arch Intern Med 1989;149:589-593.
ABSTRACT