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Serum Protein Electrophoresis Patterns in Chronic Lymphocytic LeukemiaClinical and Epidemiologic Correlations
Robin H. Miller, MD, MHS;
Martha S. Linet, MD, MPH;
Mark L. Van Natta;
Lee D. McCaffrey, MA;
Richard L. Humphrey, MD
Arch Intern Med. 1987;147(9):1614-1617.
Abstract
• Serum protein electrophoresis (SPEP) data obtained at diagnosis were available for 98 of 342 patients with chronic lymphocytic leukemia (CLL) identified in a population-based case-control epidemiologic study. Patients tested with SPEP at diagnosis were significantly younger, more likely to have lymphadenopathy, and more likely to have had their conditions diagnosed at a university hospital than those not tested. Four categories of electrophoretic patterns were identified: normal (N=56), hypogammaglobulinemia (N=28), hypergammaglobulinemia (N=11), and monoclonal gammopathy (N=3). A higher proportion of those with hypergammaglobulinemia were black, and patients with hypergammaglobulinemia and monoclonal gammopathy were more likely to die within the first year following diagnosis than patients in the other SPEP groups. No association was found, however, between SPEP pattern and a clinical staging classification for CLL. These findings suggest that SPEP may be a useful adjunct in categorizing possible subtypes of CLL and developing future clinical staging classifications.
(Arch Intern Med 1987;147:1614-1617)
Author Affiliations
From the Division of Internal Medicine, Stony Brook (NY) School of Medicine (Dr Miller); the Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health (Dr Linet, Mr Van Natta, and Ms McCaffrey), and Johns Hopkins Oncology Center (Dr Humphrey), Baltimore.
Footnotes
Accepted for publication June 22, 1987.
Read in part before the national meeting of the American Association of Cancer Research, Los Angeles, May 7, 1986.
Reprint requests to Division of Internal Medicine, T-16, Room 080, SUNY-Stony Brook, HSC, Stony Brook, NY 11794 (Dr Miller).
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