This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William J. Shergy, MD; Gary S. Gilkeson, MD; Deborah C. German, MD

Arch Intern Med. 1988;148(11):2505-2506.

Abstract
• Four adult patients with unstable angina were treated with intravenous nitroglycerin in the coronary intensive care unit. All four patients experienced an acute gouty flare while receiving or within 12 hours of discontinuing intravenous nitroglycerin. Serum uric acid levels ranged from 400 to 550 µmol/L at the time of the attack. In one patient, serum uric acid levels were followed while he was receiving intravenous nitroglycerin and were noted to increase nearly 60 µmol/L. It was speculated that the alcohol content of intravenous nitroglycerin preparations may alter serum uric acid levels and thus precipitate acute gouty flares in patients who are at increased risk for gout.

(Arch Intern Med 1988;148:2505-2506)

Author Affiliations
From the Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication May 24, 1988.

Reprint requests to Box 2918, Duke University Medical Center, Durham, NC 27710 (Dr Gilkeson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?