This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effects of the R-R Optical Isomer of Labetalol in Patients With Severe Hypertension

J. David Wallin, MD; M. Eileen Cook, MD; G. Gil Clifton, PhD; Daniel J. Blasucci, MA

Arch Intern Med. 1988;148(3):534-538.

Abstract
• Dilevalol hydrochloride, the R-R optical isomer of labetalol hydrochloride, was administered intravenously to subjects with severe hypertension. Twelve subjects with supine diastolic blood pressure of more than 115 mm Hg (mean, 124 ± 2 mm Hg) were studied. Initial doses of 25 mg of dilevalol administered as a slowly given bolus reduced blood pressure by 14/16 mm Hg. With subsequent additional boluses to a total dose of up to 600 mg, supine diastolic blood pressure was reduced to less than 95 mm Hg in ten of 12 subjects studied (mean reduction, 28 mm Hg). Side effects were minimal and upright blood pressure at the time of reduction of blood pressure to goal was not significantly different from supine blood pressure. Plasma renin activity decreased in 11 of 11 subjects studied. Plasma epinephrine concentrations did not change significantly, whereas plasma norepinephrine concentrations increased 2-fold, probably reflecting the effect of β₂-agonism on norepinephrine release. Dilevalol appears to be a safe and effective way of lowering blood pressure short term when intravenous antihypertensive therapy is indicated.

(Arch Intern Med 1988;148:534-538)

Author Affiliations
Marcia Poland

From the Department of Medicine, Section of Nephrology, Tulane University School of Medicine, New Orleans.

Footnotes
Accepted for publication Oct 15, 1987.

Reprint requests to Department of Medicine, Section of Nephrology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112 (Dr Wallin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Selected Factors That Influence Responses to Antihypertensives: Choosing Therapy for the Uncomplicated Patient
Carter et al.
Arch Fam Med 1994;3:528-535.
ABSTRACT  

Dilevalol in Severe Hypertension: A Multicenter Trial of Bolus Intravenous Dosing
Wallin et al.
Arch Intern Med 1989;149:2655-2661.
ABSTRACT