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Successful Intravenous Immune Globulin Therapy for Human Immunodeficiency Virus—Associated Thrombocytopenia
Andrew N. Pollak, MD;
Jim Janinis, MD;
David Green, MD, PhD
Arch Intern Med. 1988;148(3):695-697.
Abstract
• High-dose intravenous (IV) Immune globulin was used to treat human immunodeficiency virus (HIV)—associated thrombocytopenia four times in three patients. The average platelet count at initiation of therapy was 12x109/L (12x103/mm3), and the platelet count after therapy was 159x109/L (159x103/mm3), giving a mean Increase of 147x109/L 147x103/mm3) (1225%). The conditions of two of these patients were refractory to corticosteroids, but giving IV immune globulin along with steroids appeared to enhance the response to IV immune globulin. A review of the literature revealed that 53 (88%) of 60 patients with HIV-associated thrombocytopenia responded to IV immune globulin with platelet counts greater than 50x 109/L (50x103/mm3). We conclude that IV immune globulin therapy achieves transient elevations in platelet counts to levels that control bleeding and permit surgery in patients with severe, HIV-associated thrombocytopenia.
(Arch Intern Med 1988;148:695-697)
Author Affiliations
From the Section of Hematology/Oncology, Department of Medicine, Northwestern University Medical School, Chicago.
Footnotes
Accepted for publication Nov 13, 1987.
Reprint requests to Atherosclerosis Program, 345 E Superior St— 1407RIC, Chicago, IL 60611 (Dr Green).
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