This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Claude K. Lardinois, MD; Sherry L. Neuman

Arch Intern Med. 1988;148(6):1280-1288.

Abstract
• Hypertension is a major risk factor for arteriosclerotic vascular disease. Despite intensive antihypertensive Intervention, the risk of cardiovascular disease has not declined appreciably. Many of the antihypertensive agents have been shown to elevate total serum cholesterol and triglyceride levels or lower the high-density lipoprotein-cholesterol level. Thus, the antihypertensive agents chosen may negate the beneficial effects of a lower blood pressure. Our purpose is to review all available antihypertensive medications and their influence on lipoprotein metabolism. Choosing the antihypertensive therapy least likely to worsen or precipitate other known cardiovascular risk factors is important. Cost and side effect profiles must also be considered in choosing the best antihypertensive regimen for your patients.

(Arch Intern Med 1988;148:1280-1288)

Author Affiliations
From the Veterans Administration Medical Center and Department of Medicine and Physiology, University of Nevada School of Medicine, Reno (Dr Lardinois); and the Department of Pharmaceutical Services, University of California, Davis (Ms Neuman).

Footnotes
Accepted for publication Jan 8, 1988.

Reprint requests to Veterans Administration Medical Center, 1000 Locust St, Reno, NV 89520 (Dr Lardinois).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effects of Exercise and Weight Loss on Cardiac Risk Factors Associated With Syndrome X
Watkins et al.
Arch Intern Med 2003;163:1889-1895.
ABSTRACT | FULL TEXT  

References
Circulation 2002;106:3373-3421.
FULL TEXT  

In Vivo alpha 1-Adrenergic Lipolytic Activity in Subcutaneous Adipose Tissue of Obese Subjects
Flechtner-Mors et al.
J. Pharmacol. Exp. Ther. 2002;301:229-233.
ABSTRACT | FULL TEXT  

{beta}-Blocker-Induced Complications and the Patient With Glaucoma: Newer Treatments to Help Reduce Systemic Adverse Events
Stewart and Garrison
Arch Intern Med 1998;158:221-226.
FULL TEXT  

Long-term Effects on Plasma Lipids of Diet and Drugs to Treat Hypertension
Grimm et al.
JAMA 1996;275:1549-1556.
ABSTRACT  

Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension: Results of the Treatment of Mild Hypertension Study
Lewis et al.
Arch Intern Med 1996;156:377-385.
ABSTRACT  

Malignant Hypertension Is Accompanied by Marked Alterations in Chylomicron Metabolism
Bernardes-Silva et al.
Hypertension 1995;26:1207-1210.
ABSTRACT | FULL TEXT  

Antihypertensive Therapy in Dyslipidemic Men : Effects on Coronary Heart Disease Incidence and Total Mortality
Manttari et al.
Hypertension 1995;25:47-52.
ABSTRACT | FULL TEXT  

{beta}-Blockers, Dyslipidemia, and Coronary Artery Disease: A Reassessment
Burris
Arch Intern Med 1993;153:2085-2092.
ABSTRACT  

Therapeutic Issues in the Evaluation and Treatment of the Hypertensive Patient: White Coat Hypertension and Once Daily Dosing of Antihypertensive Agents
Wilson
Journal of Pharmacy Practice 1992;5:106-114.
ABSTRACT  

Effects of Chromium Supplementation on Serum High-Density Lipoprotein Cholesterol Levels in Men Taking Beta-Blockers: A Randomized, Controlled Trial
Roeback et al.
ANN INTERN MED 1991;115:917-924.
ABSTRACT  

Effects of Nifedipine GITS and Atenolol Monotherapy on Serum Lipids, Blood Pressure, Heart Rate, and Weight in Mild to Moderate Hypertension
Houston et al.
ANGIOLOGY 1991;42:681-690.
ABSTRACT  

Hypertension in Women: What is Really Known? The Women's Caucus, Working Group on Women's Health of the Society of General Internal Medicine
Anastos et al.
ANN INTERN MED 1991;115:287-293.
ABSTRACT  

{alpha}-Blocker Therapy of Hypertension: An Unfulfilled Promise
Khoury and Kaplan
JAMA 1991;266:394-398.
ABSTRACT  

The Effects of Low Doses of n-3 Fatty Acid Supplementation on Blood Pressure in Hypertensive Subjects: A Randomized Controlled Trial
Radack et al.
Arch Intern Med 1991;151:1173-1180.
ABSTRACT  

National Education Programs Working Group Report on the Management of Patients with Hypertension and High Blood Cholesterol
Working Group on Management of Patients with Hyper
ANN INTERN MED 1991;114:224-237.
ABSTRACT  

Pharmacologic and Nutritional Treatment of Mild Hypertension: Changes in Cardiovascular Risk Status
Oberman et al.
ANN INTERN MED 1990;112:89-95.
ABSTRACT