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Arthur P. Wheeler, MD; Robert D. B. Jaquiss, MD; John H. Newman, MD

Arch Intern Med. 1988;148(6):1321-1325.

Abstract
• To quantify physican practices in the care of patients with presumed pulmonary embolism or deep venous thrombosis, we analyzed heparin sodium orders, the intensity of anticoagulation, and complications in 65 patients with the diagnosis of deep venous thrombosis or pulmonary embolism. All patients were given heparin, for a mean (± SEM) period of 8.8 ± 0.4 days. A high percentage of patients (60%) did not have a single partial thromboplastin time (PTT) greater than 1.5 times control within the first 24 hours of heparin therapy. Not until day 8 were 90% of PTTs in therapeutic range. We Identified five common practices that led to delays in achieving a PTT greater than 1.5 times the laboratory control: (1) failure to start heparin therapy at the time of initial clinical suspicion, (2) choice of a heparin sodium bolus (mean, 5861 ± 365 U) and continuous infusion (1026 ± 148 U/h) insufficient to elevate the PTT to greater than 1.5 times control, (3) delay in obtaining the first PTT (mean, 11.7 ± 1 h after start of heparin therapy), (4) insufficient heparin dosing in response to a low PTT, and (5) excessive and prolonged reductions in heparin therapy in response to a PTT greater than three times control, leading to subtherapeutic levels in 56% of subsequent PTTs. We think that poor understanding of heparin kinetics, overcautious behavior of physicians, and high heparin requirements in this selected population account for the findings.

(Arch Intern Med 1988;148:1321-1325)

Author Affiliations
From the Center for Lung Research and Pulmonary Division, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

Footnotes
Accepted for publication Jan 20, 1988.

Reprint requests to B1308 Vanderbilt Medical Center North, Nashville, TN 37232 (Dr Wheeler).

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