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Periglomerular GranulomatosisA Limited Form of Wegener's Granulomatosis With Exclusive Renal Involvement?
Aniana Oliet, MD;
Manuel Praga, MD;
Fernando Vidaur, MD;
Alex Elósegui, MD;
Gabrierl Usera, MD;
Ignacio Bello, MD
Arch Intern Med. 1988;148(6):1377-1379.
Abstract
• Three episodes of acute renal failure, all of them requiring hemodialysis, were observed in two patients. The renal biopsy specimens showed a massive periglomerular granulomatosis with crescentic glomerulonephritis. With cyclophosphamide therapy, a dramatic improvement in renal function was observed in both patients. Although the histologic findings and the response to cyclophosphamide therapy were characteristic of Wegener's granulomatosis, there was no evidence of respiratory involvement or extrarenal manifestations throughout the patients' clinical course. We think that these cases could represent limited forms of Wegener's granulomatosis with exclusive renal involvement.
(Arch Intern Med 1988;148:1377-1379)
Author Affiliations
From the Departments of Nephrology (Drs Oliet, Praga, and Bello) and Pathology (Dr Usera), First of October Hospital, Madrid, and the Department of Nephrology, Hospital Nuestra Señora de Aránzazu, San Sebastian, Spain (Drs Vidaur and Elósegui).
Footnotes
Accepted for publication Dec 3, 1987.
Reprint requests to Department of Nephrology, Hospital 1° de Octubre, Carretera de Andalucia km 5.400, 28041 Madrid, Spain (Dr Praga).
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