Acute Response to Bronchodilator: An Imperfect Guide for Bronchodilator Therapy in Chronic Airflow Limitation

doi:10.1001/archinte.1988.00380090043011

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 148 No. 9, September 1988

Online Only
	•	Online First Table of Contents

ORIGINAL INVESTIGATIONS

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (53)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Acute Response to Bronchodilator

An Imperfect Guide for Bronchodilator Therapy in Chronic Airflow Limitation

Gordon H. Guyatt, MD; Marie Townsend; Sharon Nogradi, MSc; Stewart O. Pugsley, MD; Jana L. Keller; Michael T. Newhouse, MD

Arch Intern Med. 1988;148(9):1949-1952.

Abstract

• We conducted a four-period cross-over randomized trialin which we found that patients with chronic airflow limitationdemonstrated symptomatic improvement with both inhaled albuteroland oral theophylline. The response, however, was not uniform.We therefore tested the ability of acute change in forced expiredvolume in one second (FEV₁) following inhaled beta agonist topredict long-term symptomatic response to albuterol and theophylline.We found that the reproducibility of acute change in FEV₁ overthree repetitions was poor (intraclass correlation 0.17). Furthermore,the mean improvement in FEV₁ following inhaled albuterol acrossthe three repetitions did not relate closely to symptomaticresponse to either albuterol or theophylline. We conclude thatacute response to inhaled beta agonist is not useful for identifyingpatients with chronic airflow limitation who are likely to benefitfrom bronchodilator treatment.

(Arch Intern Med 1988;148:1949-1952)

Author Affiliations

From the Departments of Clinical Epidemiology and Biostatistics (Dr Guyatt, and Ms Townsend, Keller, and Nogradi), and Medicine (Drs Guyatt, Pugsley, and Newhouse), McMaster University, Hamilton, Ontario, Canada.

Footnotes

Accepted for publication April 15, 1988.

Presented to the Canadian Thoracic Society at a meeting of theRoyal College of Physicians and Surgeons of Canada, Winnipeg,Manitoba, Sept 12, 1987.

Reprint requests to McMaster University Health Sciences Centre,Room 3H7, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5(Dr Guyatt).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute Bronchodilator Responsiveness in Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem Cell Transplantation
Barisione et al.
Chest 2011;139:633-639.
ABSTRACT | FULL TEXT

Reversible Airflow Obstruction in Lymphangioleiomyomatosis
Taveira-DaSilva et al.
Chest 2009;136:1596-1603.
ABSTRACT | FULL TEXT

{beta}2-Adrenergic Receptor Genetic Polymorphisms and Short-term Bronchodilator Responses in Patients With COPD
Hizawa et al.
Chest 2007;132:1485-1492.
ABSTRACT | FULL TEXT

Tiotropium and Simplified Detection of Dynamic Hyperinflation
Gelb et al.
Chest 2007;131:690-695.
ABSTRACT | FULL TEXT

Inhaler choice in primary practice
Chapman et al.
Eur Respir Rev 2005;14:117-122.
ABSTRACT | FULL TEXT

Interpretative strategies for lung function tests
Pellegrino et al.
Eur Respir J 2005;26:948-968.
FULL TEXT

Simplified Detection of Dynamic Hyperinflation
Gelb et al.
Chest 2004;126:1855-1860.
ABSTRACT | FULL TEXT

Regular inhaled short acting {beta}2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis
Ram and Sestini
Thorax 2003;58:580-584.
ABSTRACT | FULL TEXT

Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
Palmer et al.
Hum Mol Genet 2003;12:1199-1210.
ABSTRACT | FULL TEXT

Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest
Boni et al.
Thorax 2002;57:528-532.
ABSTRACT | FULL TEXT

Statistical Issues in Short-Term Trials in Asthma
Senn
Drug Information Journal 1993;27:779-791.
ABSTRACT

Aminophylline Therapy for Acute Bronchospastic Disease in the Emergency Room
Wrenn et al.
ANN INTERN MED 1991;115:241-247.
ABSTRACT

Predicting Response to Bronchodilator Therapy in Chronic Obstructive Pulmonary Disease
Pratter and Irwin
Arch Intern Med 1988;148:1909-1910.
ABSTRACT

| | |