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Plasma Lipids in Patients With Type I Diabetes MellitusInfluence of Race, Gender, and Plasma Glucose Control: Lipids Do Not Correlate With Glucose Control in Black Women
Clay F. Semenkovich, MD;
Richard E. Ostlund, Jr, MD;
Kenneth B. Schechtman, PhD
Arch Intern Med. 1989;149(1):51-56.
Abstract
• Plasma lipids and hemoglobin A1 were measured in 544 type I diabetic patients. Hemoglobin A1 was positively correlated with the levels of total plasma cholesterol, total triglycerides, and low-density lipoprotein cholesterol and negatively correlated with the level of high-density lipoprotein cholesterol in the entire biracial group. These relationships between plasma lipids and hemoglobin A1 were not present in black women. In the white diabetic population a reduction in hemoglobin A1 of one percentage point was statistically associated with a decrease of 0.16 to 0.17 mmol/L in total plasma cholesterol, a decrease of 0.10 to 0.13 mmol/L in low-density lipoprotein cholesterol, and a reduction of 0.12 to 0.14 mmol/L in triglycerides. These findings suggest that race and gender are important determinants of the response of plasma lipids to glucose control in type I diabetes mellitus.
(Arch Intern Med 1989;149:51-56)
Author Affiliations
From the Metabolism Division, Department of Medicine (Drs Semenkovich and Ostlund) and Department of Biostatistics (Dr Schechtman), Washington University School of Medicine, St Louis. Dr Semenkovich is now with the Baylor College of Medicine, Houston.
Footnotes
Accepted for publication July 28, 1988.
Reprint requests to Metabolism Division, Box 8127, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110 (Dr Ostlund).
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