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A Prospective Study

Emanuel Sikuler, MD; Victor Guetta, MD; Arie Keynan, MD; Lily Neumann, PhD; Francisc Schlaeffer, MD

Arch Intern Med. 1989;149(10):2246-2248.

Abstract
• Eighty-four patients with bacteremia were surveyed prospectively for biochemical markers of liver damage. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and bilirubin levels were elevated in 44 (53%), 39 (47%), 45 (54%), and 5 (6%) of the patients on the first determination (2.0 ± 0.1 days after onset of fever) and in 11 (13%), 17 (20%), 26 (31%), and 1 (1%) on the second determination (5.4 ± 0.2 days after onset of fever), respectively. The elevation rarely exceeded three times the upper limit of normal. One patient had severe jaundice. An abnormality of at least one of these values was found in 55 patients (65%). There were no differences in site of infection, bacteria isolated, and outcome between patients with and without biochemical abnormalities. We conclude that in adult patients with bacteremia, elevation of liver enzymes and bilirubin is common, usually mild, of short duration, and of no prognostic significance.

(Arch Intern Med. 1989;149:2246-2248)

Author Affiliations
From the Departments of Medicine B and Epidemiology, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.

Footnotes
Accepted for publication April 21, 1989.

Reprint requests to Department of Medicine B, Soroka Medical Center, PO Box 151, Beer-Sheva, Israel 84104 (Dr Sikuler).

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