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Samuel Smith, MD; Janis Swain, MS, RD; Edward M. Brown, MD; Grace Wyshak, PhD; Tenley Albright, MD; Veronica A. Ravnikar, MD; Isaac Schiff, MD

Arch Intern Med. 1989;149(11):2517-2519.

Abstract
• A variety of nutritional factors influence the bioavailability of calcium and increase a woman's risk of osteoporosis. Eight healthy women completed an 8-week metabolic study designed to investigate the effect of nonalcoholic carbonated beverage consumption on calcium metabolism. Compared with women receiving a control diet, women consuming a diet high in nonalcoholic carbonated beverages demonstrated similar mean serum levels of calcium, ionized calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 1,25-dihydroxyvitamin D3, and osteocalcin. Twenty-four-hour urine volume, creatinine clearance, calcium-creatinine ratio, and phosphorus-creatlnine ratio were similar during consumption of the diet high in nonalcoholic carbonated beverages and the control diet. Twenty-fourhour cyclic adenosine monophosphate–creatinine ratio was significantly lower in women consuming the diet high in nonalcoholic carbonated beverage compared with women receiving the control diet (342±27.4 nmol/mmol vs 409±22.1 nmol/mmol). Consumption of a diet high in nonalcoholic carbonated beverages on a short-term basis does not appear to affect adversely the serum or urinary markers of calcium metabolism.

(Arch Intern Med. 1989;149:2517-2519)

Author Affiliations
From the Departments of Obstetrics and Gynecology (Drs Smith, Schiff, and Ravnikar), Medicine (Drs Wyshak and Albright), and Endocrine-Hypertension (Dr Brown), and the Clinical Research Center (Ms Swain), Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Dr Smith is now with the Sinai Hospital of Baltimore (Md).

Footnotes
Accepted for publication July 12, 1989.

Reprint requests to Division of Reproductive Endocrinology-Infertility, Sinai Hospital of Baltimore, Belvedere at Greenspring Avenue, Baltimore, MD 21215 (Dr Smith).

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