 |
|
Pamidronate Sodium and Calcitonin-Resistant Paget's DiseaseImmediate Response in a Patient
Sabra Drake, MD;
James D. Massie, MD;
Arnold E. Postlethwaite, MD;
Genaro M. A. Palmieri, MD
Arch Intern Med. 1989;149(2):401-403.
Abstract
| |
• One three-day course of intravenous pamidronate sodium (3-amino-1 -hydroxypropylidene-1,1-bisphosphonate), 30 mg/d, in a patient with calcitonin-resistant Paget's disease resulted in the following: marked clinical improvement within two weeks; normalization of urinary hydroxyproline value; fall of serum alkaline phosphatase value (900 to 250 U/L); a rise in serum osteocalcin value by the tenth week that returned to pretreatment levels in the 16th week; transient hypocalcemia with elevation of parathyroid hormone value; reduction in urinary calcium excretion; and improvement in bone scans. No adverse reactions occurred, with the exception of mild and transient hyperpyrexia for 48 hours during pamidronate administration. White blood cell counts did not change and serum interleukin 1 was undetectable before and after treatment with pamidronate. Pamidronate seems to be highly effective in the treatment of Paget's disease of the bone, but its profound effects on mineral and bone metabolism require close monitoring during the short-term period of intravenous treatment.
(Arch Intern Med 1989;149:401-403)
Author Affiliations
From the Departments of Medicine (Drs Drake, Postlethwaite, and Palmieri) and Radiology (Dr Massie), University of Tennessee at Memphis, and the Veterans Administration Medical Center, Memphis.
Footnotes
Accepted for publication Sept 20, 1988.
Read in part before the Annual Meeting of the Adult Bone and Mineral Working Group, Indianapolis, June 14, 1987.
Reprint requests to University of Tennessee Memphis, 956 Court Ave, Room E336, Memphis, TN 38163 (Dr Palmieri).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
