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Cardiac Status After Four Years in a Trial on Nutritional Therapy for High Blood Pressure
Rose Stamler, MA;
Richard H. Grimm, Jr, MD, PhD;
Alan R. Dyer, PhD;
James V. Talano, MD;
Ronald Prineas, MBBS, PhD;
Richard Crow, MD;
Reuben Berman, MD;
Flora C. Gosch, MD;
Patricia Elmer, PhD, RD;
Jeremiah Stamler, MD
Arch Intern Med. 1989;149(3):661-665.
Abstract
• A randomized controlled trial demonstrated the ability of nutritional intervention in place of antihypertensive drugs to maintain blood pressure at normal levels for four years in 39% of less severely hypertensive patients whose blood pressure was previously well controlled by pharmacologic treatment. However, average blood pressures during the trial for patients in the intervention group were higher than those for a comparison group that continued to receive drug therapy throughout the study. Holter monitoring, echocardiography, roentgenography, and electrocardiography done at four years to determine whether blood pressure differences between groups were associated with differences in cardiac status did not indicate any differences in cardiac status favorable to one group compared with the other. Further investigation in larger samples is needed to assess any long-term differences in cardiac status based on such alternate therapies.
(Arch Intern Med 1989;149:661-665)
Author Affiliations
From Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago (Ms Stamler and Drs Dyer, Talano, Gosch, and Stamler); School of Public Health, Division of Epidemiology (Drs Grimm and Prineas), Laboratory of Physiological Hygiene (Drs Crow and Elmer), School of Public Health, Biometry Division (Dr Crow), University of Minnesota, and Mount Sinai Hospital (Dr Berman), Minneapolis.
Footnotes
Accepted for publication Oct 17, 1988.
Reprint requests to Department of Community Health and Preventive Medicine, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611 (Ms Stamler).
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