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Alterations in Oxygen Saturation and Ventilation After Intravenous Sedation for Peritoneoscopy
Charles E. Brady III, MD;
Lionel E. Harkleroad, MA;
Wayne P. Pierson, PhD
Arch Intern Med. 1989;149(5):1029-1032.
Abstract
• The effect of intravenous sedation on oxygen saturation and ventilation was studied in 11 patients undergoing peritoneoscopy. Oxygen saturation (mean ± SD) decreased from baseline (94.7% ± 1.7%) to nadir (78.6% ± 10.7%) after sedation. Respiratory depression was evident in these patients by concomitant decreases in minute ventilation and tidal volume. Baseline to nadir arterial blood gas changes in eight patients were consistent with hypoventilation and also suggested a superimposed ventilation perfusion mismatch. Mean respiratory rate did not significantly change during peritoneoscopy. Peritoneal gas insufflation stimulated increased ventilation and oxygen saturation, but no further changes in Pco2 or pH. We conclude that serious arterial oxygen desaturation and possibly some ventilation perfusion mismatch occur after sedation with intravenously administered meperidine-diazepam for peritoneoscopy with resultant hypoxemia, hypercarbia, and acidosis.
(Arch Intern Med. 1989;149:1029-1032)
Author Affiliations
From the Gastroenterology Service, Pulmonary Function Laboratory, and Clinical Investigative Facility, Wilford Hall, US Air Force Medical Center, San Antonio, Tex. Dr Brady is now with the University of Texas Health Science Center, San Antonio.
Footnotes
Accepted for publicaton December 6,1988.
The opinions or assertions contained herein are those of the authors and are not to be construed as reflecting the views of the United States Air Force or the Department of Defense.
Presented in part at the annual meeting of the American Society for Gastrointestinal Endoscopy, New York, NY, May 1981.
Reprint requests to Division of Gastroenterology and Nutrition, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284-7878 (Dr Brady).
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