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Glucose Intolerance After Short-term Administration of Corticosteroids in Healthy SubjectsPrednisone, Deflazacort, and Betamethasone
Gianfranco Pagano, MD;
Alberto Bruno, MD;
Paolo Cavallo-Perin, MD;
Lorella Cesco, MD;
Bruno Imbimbo, MD
Arch Intern Med. 1989;149(5):1098-1101.
Abstract
• Glucocorticoid-induced glucose intolerance has been related to the dose, duration of treatment, and steroid compound. However, a clear demonstration of this phenomenon is still lacking for fluorinated corticosteroids. We performed an oral glucose tolerance test in six healthy volunteers after the short-term administration of deflazacort (18 + 18 mg), prednisone (15 + 15 mg), and betamethasone disodium phosphate (1.5 +1.5 mg) at equivalent anti-inflammatory doses, in random sequence, and in a triple crossover design. Fasting plasma glucose levels were not modified by deflazacort, whereas fasting plasma glucose levels together with insulin and C-peptide values were progressively and significantly increased by prednisone and betamethasone. During oral glucose tolerance testing a significant increase in the plasma glucose and insulin peaks was recorded after betamethasone and, to a lesser extent, after prednisone and deflazacort. These results suggest that betamethasone induces greater glucose intolerance and insulin resistance than prednisone and deflazacort.
(Arch Intern Med. 1989;149:1093-1101)
Author Affiliations
From the Institute of Internal Medicine, University of Turin (Drs Pagano, Bruno, Cavallo-Perin, and Cesco), and the Gruppo Lepetit SpA Grandate, Como (Dr Imbimbo), Italy.
Footnotes
Accepted for publication November 8,1988.
Reprint requests to Istituto Medicina Interna, Università di Torino, C. Polonia 14, 10126 Torino, Italy (Dr Pagano).
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