 |
|
Large Phosphate Shifts With Treatment for Hyperglycemia
Nancy J. V. Bohannon, MD
Arch Intern Med. 1989;149(6):1423-1425.
Abstract
• Although hypophosphatemia is known to commonly accompany therapy for hyperglycemia, it is not generally appreciated that severe life-threatening depletion of phosphate may occur. I followed up two patients who had precipitous drops during intravenous insulin therapy for diabetic ketoacidosis and hyperosmolar nonketotic state. The patient with diabetic ketoacidosis had a phosphate level nadir that equaled the lowest recorded phosphate level in a living human (0.03 mmol/L). Because (1) serum phosphate levels do not reflect total body phosphate stores, (2) rapid shifts of phosphorus can occur among body compartments, and (3) severe hypophosphatemia is potentially life-threatening, phosphate levels should be frequently monitored during therapy for hyperglycemia and intervention should be undertaken if phosphate levels fall below 0.5 mmol/L.
(Arch Intern Med. 1989;149:1423-1425)
Author Affiliations
From St Luke's Hospital, San Francisco, Calif.
Footnotes
Accepted for publication December 6,1988.
Reprints not available.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
Goetz et al.
Proc. Natl. Acad. Sci. USA 2010;107:407-412.
ABSTRACT
| FULL TEXT
Diabetic Ketoacidosis in Infants, Children, and Adolescents: A consensus statement from the American Diabetes Association
Wolfsdorf et al.
Diabetes Care 2006;29:1150-1159.
FULL TEXT
|
