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A Clinical Review

Lora S. Regan, MD

Arch Intern Med. 1989;149(8):1741-1744.

Abstract
• Hepatocellular carcinoma occurs primarily in individuals with chronic hepatitis B infection and cirrhosis. This tumor is curable only when diagnosed at an early stage and then surgically resected. Therefore, screening tests have been used to identify small tumors in high-risk patients. Currently, the most sensitive and specific tests available involve measurement of serum fetoprotein levels and high-resolution ultrasonography. The results of these tests are often complementary in making a diagnosis. To be most cost-effective, the frequency of screening can be adjusted to the degree of risk of hepatocellular carcinoma.

(Arch Intern Med. 1989;149:1741-1744)

Author Affiliations
From the Division of General Internal Medicine, Department of Medicine, University of California, San Francisco. Dr Regan is now in private practice, Redwood City, Calif.

Footnotes
Accepted for publication May 19, 1989.

Reprints not available.

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