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Liver Disease Associated With Exposure to 1,1,1 -Trichloroethane
Michael J. Hodgson, MD, MPH;
Alma E. Heyl, RT;
David H. Van Thiel, MD
Arch Intern Med. 1989;149(8):1793-1798.
Abstract
• 1,1,1-Trichloroethane is a halogenated hydrocarbon solvent commonly used in industry because of its supposed lack of hepatotoxicity. Nonetheless, animal studies performed by several independent groups have shown the solvent to induce fat deposition, vacuolar degeneration, and centrilobular necrosis, changes similar to those seen after exposure to carbon tetrachloride, albeit of a much reduced magnitude, in animals exposed to the agent. Four patients with fatty liver disease whose work entailed substantial exposure to this agent were seen at the University of Pittsburgh (Pa). Based on this clinical experience, we believe that 1,1,1-trichloroethane should be reconsidered as an agent with potential hepatotoxicity in man.
(Arch Intern Med. 1989;149:1793-1798)
Author Affiliations
From the Occupational and Environmental Medicine Program, Division of General Medicine (Dr Hodgson), and the Division of Gastroenterology (Ms Heyl and Dr Van Thiel), Department of Medicine, University of Pittsburgh (Pa) School of Medicine.
Footnotes
Accepted for publication January 13, 1989.
Reprint requests to Occupational and Environmental Medicine Program, University of Pittsburgh School of Medicine, Lothrop Hall 149,190 Lothrop St, Pittsburgh, PA 15261 (Dr Hodgson).
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