This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (43)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Thorsteinn Blöndal, MD

Arch Intern Med. 1989;149(8):1818-1821.

Abstract
• In a placebo-controlled, double-blind, 2-year prospective study, 182 smokers were given either nicotine polacrilex gum containing 4 mg of nicotine (n=92) or a placebo (n=90). The number of participants abstinent at 2-year follow-up was 41 (44.6%) of 92 in the nicotine group vs 28 (31.1%) of 90 in the placebo group. Abstinence rates for daily nicotine gum users (n = 64) at 12 months and again at 24 months remained 48.4%, as compared with 26.1% and 31.9% for the daily placebo gum users (n = 69). Of participants with a high nicotine-dependence score, those allotted to the nicotine group rather than to the placebo group were 13 times more likely to be abstaining at the 2-year follow-up. Use of nicotine polacrilex gum, therefore, can substantially aid in stopping smoking, particularly among highly dependent smokers.

(Arch Intern Med. 1989;149:1818-1821)

Author Affiliations
From the Reykjavik (Iceland) Health Centre, Clinic for Tuberculosis and Lung Diseases.

Footnotes
Accepted for publication April 26, 1989.

Reprint requests to Clinic for Tuberculosis and Lung Diseases, Reykjavik Health Centre (Heilsuverndarstödin), Barónstigur 47, 101 Reykjavik, Iceland (Dr Blöndal).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pharmacotherapies for smoking cessation: a meta-analysis of randomized controlled trials
Eisenberg et al.
CMAJ 2008;179:135-144.
ABSTRACT | FULL TEXT  

Nicotine replacement therapy for long-term smoking cessation: a meta-analysis.
Etter and Stapleton
Tobacco Control 2006;15:280-285.
ABSTRACT | FULL TEXT  

Diagnosis and treatment of nicotine dependence with emphasis on nicotine replacement therapy. A status report
Balfour et al.
Eur Heart J 2000;21:438-445.
ABSTRACT  

Cost-effectiveness of the Transdermal Nicotine Patch as an Adjunct to Physicians' Smoking Cessation Counseling
Fiscella and Franks
JAMA 1996;275:1247-1251.
ABSTRACT  

Effectiveness of the 4-mg Dose of Nicotine Polacrilex for the Initial Treatment of High-Dependent Smokers
Sachs
Arch Intern Med 1995;155:1973-1980.
ABSTRACT  

Prospective study of factors predicting outcome of transdermal nicotine treatment in smoking cessation
Gourlay et al.
BMJ 1994;309:842-846.
ABSTRACT | FULL TEXT  

How effective is nicotine replacement therapy in helping people to stop smoking?
Tang et al.
BMJ 1994;308:21-26.
ABSTRACT | FULL TEXT  

Long-term Use of Nicotine vs Placebo Gum
Hughes et al.
Arch Intern Med 1991;151:1993-1998.
ABSTRACT  

"The Facts Concerning the Recent Carnival of Smoking in Connecticut" and Elsewhere
Williams et al.
ANN INTERN MED 1991;115:59-63.
ABSTRACT