 |
|
Effects of Modest Doses of Omega-3 Fatty Acids on Lipids and Lipoproteins in Hypertriglyceridemic SubjectsA Randomized Controlled Trial
Colleen Deck, PharmD;
Kenneth Radack, MD
Arch Intern Med. 1989;149(8):1857-1862.
Abstract
• Unlike the well-established hypotriglyceridemic effect of omega-3 fatty acid supplementation, the influence of more clinically tolerable doses on lipoproteins and apolipoproteins is less well characterized. Therefore, we compared the relative effects of modest doses of omega-3 fatty acid supplementation with a corn oil control on lipids, lipoproteins, and apolipoproteins in a randomized, double-blind controlled crossover study. Eight hypertriglyceridemic subjects ingested 4.6 g/d of omega-3 fatty acids or 5.4 g/d of linoleic acid (supplied as corn oil) for 8 weeks, then crossed over to the alternative encapsulated oil for another 8 weeks, following an interposed 4-week wash-out period. Compared with the corn oil control, fish oil supplementation caused a significant reduction in triglyceride levels by a mean of 2.21 mmol/L and increased the high-density lipoprotein cholesterol by a mean of 0.13 mmol/L, associated with a significant rise in the high-density lipoprotein 3 subfraction. Furthermore, there was a significant increase in low-density lipoprotein (LDL) apolipoprotein B levels by a mean of 0.246 g/L. Compared with corn oil, no statistically significant change for LDL cholesterol or other apolipoprotein levels occurred, although LDL cholesterol showed a mild elevation. These data suggest that unlike large doses of omega-3 fatty acids, the hypotriglyceridemic effect of modest amounts of encapsulated fish oil supplementation is unaccompanied by favorable changes in LDL cholesterol or LDL apolipoprotein B levels; the potential therapeutic usefulness of modest doses of dietary fish oil for the treatment of hypertriglyceridemia, therefore, may be limited.
(Arch Intern Med. 1989;149:1857-1862)
Author Affiliations
From the Departments of Pharmacy, University Hospital, University of Cincinnati (Dr Deck) and Internal Medicine, University of Cincinnati College of Medicine (Dr Radack), Ohio.
Footnotes
Accepted for publication May 5,1989.
Reprints to Division of General Internal Medicine, Mail Location 535, 231 Bethesda Ave, Cincinnati, OH 45267 (Dr Radack).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The Triglyceride-Lowering Effects of a Modest Dose of Docosahexaenoic Acid Alone Versus in Combination with Low Dose Eicosapentaenoic Acid in Patients with Coronary Artery Disease and Elevated Triglycerides
Schwellenbach et al.
J. Am. Coll. Nutr. 2006;25:480-485.
ABSTRACT
| FULL TEXT
An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets
Pedersen et al.
J. Lipid Res. 2000;41:1901-1911.
ABSTRACT
| FULL TEXT
The Effects of Low Doses of n-3 Fatty Acid Supplementation on Blood Pressure in Hypertensive Subjects: A Randomized Controlled Trial
Radack et al.
Arch Intern Med 1991;151:1173-1180.
ABSTRACT
|
