This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

The Princess Margaret Hospital Experience and a Review of the Literature

Michael Lishner, MD; Richard G. Perrin, MD; Ronald Feld, MD; Hans A. Messner, MD; Peter G. Tuffnell, FRCPath; Tahany Elhakim, MSc; Anne Matlow, MD; John E. Curtis, MD

Arch Intern Med. 1990;150(1):173-176.

Abstract
• The complications associated with the use of Ommaya reservoirs in 106 patients with meningeal involvement due to malignant disease are reviewed. Twenty-seven patients had acute lymphoblastic leukemia, 12 acute myelogenous leukemia, 3 chronic lymphocytic leukemia, 34 lymphoma, 29 carcinoma, and 1 chronic myelocytic leukemia. There were 11 technical complications, including 1 death due to misplacement of the catheter, 2 mild intraventricular hemorrhages, and 5 malfunctioning reservoirs; 3 required craniotomies (1 for subdural hematoma and 2 for subdural hygroma); 13 cases of bacterial meningitis occurred in 10 patients. One patient died of Staphylococcus aureus meningitis. The organisms causing the other infections were mainly coagulase-negative staphylococci (8 cases) or Propionibacterium acnes (2 cases). The projected infection rate for all patients (by Kaplan-Meier analysis) during the first year following insertion of a reservoir was 15%. Successful use of Ommaya reservoirs requires expert surgical implantation and meticulous care during accessing to minimize complications.

(Arch Intern Med. 1990;150:173-176)

Author Affiliations
From the Departments of Medicine and Pathology, Ontario Cancer Institute, (Drs Lishner, Feld, Messner, Tuffnell, Elhakim, and Curtis) and Departments of Surgery and Medicine, Wellesley Hospital (Drs Perrin and Matlow), Toronto, Canada.

Footnotes
Accepted for publication August 15,1989.

Presented at the American Society of Clinical Oncology meeting, New Orleans, La, May 1988.

Reprint requests to Ontario Cancer Institute, 500 Sherbourne St, Toronto, Ontario, Canada M4X1K9 (Dr Curtis).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma
Freeman et al.
Neuro Oncol 2006;8:89-95.
ABSTRACT | FULL TEXT  

Sensorineural Hearing Loss Associated with Intrathecal Vancomycin
Klibanov et al.
The Annals of Pharmacotherapy 2003;37:61-65.
ABSTRACT | FULL TEXT  

Pediatric Leptomeningeal Metastases: Outcome Following Combined Therapy
Chamberlain
J Child Neurol 1997;12:53-59.
ABSTRACT  

Topical Review: A Review of Leptomeningeal Metastases in Pediatrics
Chamberlain
J Child Neurol 1995;10:191-199.
ABSTRACT