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Absence of Drug Interaction Between Heparin and NitroglycerinRandomized Placebo-Controlled Crossover Study
Volker Bode, PhD;
Dieter Welzel, MD;
Gerhard Franz, PhD
Arch Intern Med. 1990;150(10):2117-2119.
Abstract
• The purpose of this randomized crossover study was to determine whether nitroglycerin interacts with heparin in terms of its anticoagulative properties as determined by activated partial thromboplastin time and thrombin time. Eight healthy adults were given either a 60-minute intravenous infusion of 5 mg of nitroglycerin or a 0.9% sodium chloride solution subsequent to the administration of an intravenous injection of 5000 U of heparin. No nitroglycerin-related drug interference with heparin was observed as measured by the activated partial thromboplastin time and the thrombin time.
(Arch Intern Med. 1990;150:2117-2119)
Author Affiliations
Udo Polensky
From the Department of Chemistry and Pharmacology, University of Regensburg (West Germany) (Drs Bode and Franz), and the Department of Clinical Research, Sandoz AG, Nürnberg, West Germany (Dr Welzel and Mr Polensky).
Footnotes
Accepted for publication March 23, 1990.
Reprint requests to Deutschherrnstrasse 15, D-8500 Nürnberg 80, West Germany (Dr Bode).
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