This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (20)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joseph T. Hanlon, PharmD, MSc; Mark Linzer, MD; Julia P. MacMillan, MPH; Ingrid K. Lewis, PharmD; Alonzo A. Felder

Arch Intern Med. 1990;150(11):2309-2312.

Abstract
• The purpose of this study was to determine whether syncope and presyncope were associated with drug therapy in 70 patients referred to a tertiary care ambulatory clinic. Drug use information was obtained, validated, and classified by its potential to cause syncope and presyncope. Utilizing a standardized adverse drug reaction algorithm, nine (13%) of the 70 patients were rated as having probable drug-induced syncope and presyncope events. Overall, 12 medications were implicated. Patients with probable adverse drug reactions were older, and taking more medications, or taking an antihypertensive. Seven of the nine patients with probable adverse drug reactions were previously classified as having syncope of unknown origin after their initial clinic evaluation. Syncope and presyncope are commonly associated with adverse drug reactions, especially in the elderly and those taking multiple medications.

(Arch Intern Med. 1990;150:2309-2312)

Author Affiliations
From the Division of Geriatric Medicine (Dr Hanlon), the Center for the Study of Aging and Human Development (Dr Hanlon and Ms MacMillan), and the Division of General Internal Medicine (Dr Linzer and Mr Felder), Duke University Medical Center, Durham, NC; and the School of Pharmacy, University of North Carolina at Chapel Hill (Drs Hanlon and Lewis). Dr Linzer is now with the Division of General Internal Medicine, New England Medical Center, Boston, Mass; Ms MacMillan is with Quintiles, Research Triangle Park, NC; and Dr Lewis with the Department of Pharmacy, Veterans AffairsMedical Center, Durham, NC.

Footnotes
Accepted for publication June 4,1990.

Reprint requests to Center for the Study of Aging and Human Development, Box 3003, Duke University Medical Center, Durham, NC 27710 (Dr Hanlon).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Withdrawing cardiovascular medications at a syncope clinic
Alsop and Mac Mahon
Postgrad. Med. J. 2001;77:403-405.
ABSTRACT | FULL TEXT  

Dizziness: State of the Science
Sloane et al.
ANN INTERN MED 2001;134:823-832.
ABSTRACT | FULL TEXT  

Continuous haemodynamic monitoring in an unusual case of swallow induced syncope
Deguchi and Mathias
J. Neurol. Neurosurg. Psychiatry 1999;67:220-222.
ABSTRACT | FULL TEXT