The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

doi:10.1001/archinte.1990.00390220065013

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Vol. 150 No. 11, November 1990

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The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

P. Barton Duell, MD; Edwin L. Bierman, MD

Arch Intern Med. 1990;150(11):2317-2320.

Abstract

• The objective of this study was to clarify the complexand uncertain relationship between endogenous sex hormones andhigh-density lipoprotein (HDL) cholesterol levels in healthymen. Fifty-five healthy adult men were consecutively recruitedfrom an ongoing cross-sectional study of cardiovascular diseaserisk factors from a lipid research clinic at the Universityof Washington, Seattle. Subjects receiving medication were excluded.Multiple linear regression analysis identified several factorsthat correlated highly significantly with HDL cholesterol levels,including alcohol intake; frequency of strenuous exercise; age;levels of total cholesterol, low-density lipoprotein cholesterol,and triglyceride; and carbohydrate intake. Nearly 80% of theheterogeneity in HDL cholesterol levels could be accounted forby these factors. Despite finding significant correlations withfactors known to influence HDL cholesterol levels, no correlationwith estradiol level, testosterone level, or the ratio of estradiolto testosterone levels was apparent. In conclusion, endogenoussex hormones do not appear to influence HDL cholesterol levelsin healthy adult men. Alternatively, a large proportion of theheterogeneity in HDL levels in this group of men can be accountedfor by environmental factors. The disparity between this conclusionand others may be partially due to differences in accountingfor these confounding variables.

(Arch Intern Med. 1990;150:2317-2320)

Author Affiliations

From the Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle. Dr Duell is now with the Division of Endocrinology, Metabolism, and Nutrition, Oregon Health Sciences University, Portland.

Footnotes

Accepted for publication June 4,1990.

Read in part before the 70th Annual Session, American Collegeof Physicians, San Franscisco, Calif, April 14,1989.

Reprints not available.

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