Determinants of Vertebral Mineral Density in Patients Receiving Long-term Glucocorticoid Therapy

doi:10.1001/archinte.1990.00390230093012

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 150 No. 12, December 1990

Online Only
	•	Online First Table of Contents

ORIGINAL INVESTIGATIONS

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (121)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Determinants of Vertebral Mineral Density in Patients Receiving Long-term Glucocorticoid Therapy

Ian R. Reid, MD; Stuart W. Heap, FRACR

Arch Intern Med. 1990;150(12):2545-2548.

Abstract

• This study addresses the impact of clinical and biochemicalfactors on the bone density of patients receiving glucocorticoidtherapy. Vertebral mineral density was measured by quantitativecomputed tomography in 35 patients aged 17 to 77 years who hadreceived therapeutic glucocorticoid drugs for 0.1 to 22 years.The mean (± SEM) vertebral mineral density z score inthe subjects was -1.7±0.2. z score was unrelated to underlyingdiagnosis, sex, or age but was significantly related to theduration of previous steroid therapy (r= -.38) and to the totalcumulative glucocorticoid dose (r = -.50). The rate of changeof bone density in 16 of these subjects followed up over a periodof 12 months was - 8.9% and was significantly greater in subjectstaking more than 12.5mg of prednisone per day. Bone loss wasnot influenced by sex, age, duration of previous steroid treatment,or diagnosis and was not predictable from biochemical measuresof calcium metabolism.

(Arch Intern Med. 1990;150:2545-2548)

Author Affiliations

From the Departments of Medicine (Dr Reid) and Radiology (Dr Heap), University of Auckland (New Zealand).

Footnotes

Accepted for publication June 4,1990.

Reprint requests to the Department of Medicine, University ofAuckland, Auckland, New Zealand (Dr Reid).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Subsequent Fracture after Percutaneous Vertebroplasty Can Be Predicted on Preoperative Multidetector Row CT
Hiwatashi et al.
Am. J. Neuroradiol. 2009;30:1830-1834.
ABSTRACT | FULL TEXT

Gut, inflammation and osteoporosis: basic and clinical concepts
Tilg et al.
Gut 2008;57:684-694.
ABSTRACT | FULL TEXT

Patients with Osteoporosis on Steroid Medication Tend to Sustain Subsequent Fractures
Hiwatashi and Westesson
Am. J. Neuroradiol. 2007;28:1055-1057.
ABSTRACT | FULL TEXT

Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data
Da Silva et al.
Ann Rheum Dis 2006;65:285-293.
ABSTRACT | FULL TEXT

Loss of Bone Density with Inhaled Triamcinolone in Lung Health Study II
Scanlon et al.
Am. J. Respir. Crit. Care Med. 2004;170:1302-1309.
ABSTRACT | FULL TEXT

Treatment Considerations for Vertebroplasty in Men
Hammond et al.
Am. J. Neuroradiol. 2004;25:639-641.
ABSTRACT | FULL TEXT

The Role of Parathyroid Hormone in the Pathogenesis of Glucocorticoid-Induced Osteoporosis: A Re-Examination of the Evidence
Rubin and Bilezikian
J. Clin. Endocrinol. Metab. 2002;87:4033-4041.
FULL TEXT

The Impact of Oral Corticosteroid Use on Bone Mineral Density and Vertebral Fracture
Walsh et al.
Am. J. Respir. Crit. Care Med. 2002;166:691-695.
ABSTRACT | FULL TEXT

Prevalence of vertebral deformities and symptomatic vertebral fractures in corticosteroid treated patients with rheumatoid arthritis
de Nijs et al.
Rheumatology (Oxford) 2001;40:1375-1383.
ABSTRACT | FULL TEXT

Glucocorticoid Osteoporosis: Reid IR Glucocorticoid osteoporosis J Intensive Care Med 1999, 14231-242
Reid
J Intensive Care Med 1999;14:231-242.

Glucocorticoids Regulate the Expression of the Human Osteoblastic Endothelin A Receptor Gene
Borcsok et al.
JEM 1998;188:1563-1573.
ABSTRACT | FULL TEXT

Association between Corticosteroid Use and Vertebral Fractures in Older Men with Chronic Obstructive Pulmonary Disease
MCEVOY et al.
Am. J. Respir. Crit. Care Med. 1998;157:704-709.
ABSTRACT | FULL TEXT

Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?
Lems et al.
Ann Rheum Dis 1997;56:357-363.
ABSTRACT | FULL TEXT

| | |